SPRY4 and TESK1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SPRY4	TESK1
Description		sprouty RTK signaling antagonist 4	testis associated actin remodelling kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Focal Adhesion Ruffle Membrane	Nucleus Cytoplasm Centrosome Cytosol Cytoplasmic Vesicle Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Inhibitor Activity Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein C-terminus Binding Protein Kinase Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Substrate Adhesion-dependent Cell Spreading	Positive Regulation Of Protein Phosphorylation Spermatogenesis Peptidyl-tyrosine Phosphorylation Actin Cytoskeleton Organization Negative Regulation Of Protein Autophosphorylation Regulation Of Protein Localization Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Phosphorylation Positive Regulation Of Stress Fiber Assembly Establishment Of Vesicle Localization Negative Regulation Of Protein Serine/threonine Kinase Activity Glomerular Visceral Epithelial Cell Migration Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cilium Assembly
Pathways			Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs			Fostamatinib
Diseases
GWAS		Asthma ( 31959851 29273806) Body mass index ( 28552196) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Gut microbiota (bacterial taxa) ( 27723756) Height ( 31562340) Inflammatory bowel disease ( 23128233) Physiological traits ( 31902109) Systolic blood pressure ( 30578418) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 19483681 28604728 28604732 23666239 23666240)
Interacting Genes		17 interacting genes: ADAM12 COL8A1 CREB5 EFEMP2 FHL2 HOXA1 KLHL38 KRTAP5-11 NUTF2 OTX1 POU4F2 RAF1 RIN3 TESK1 TNS2 VENTX ZDHHC17	7 interacting genes: ABCB4 ARAF CFL1 PFKL SPRY4 YWHAB YY1
Entrez ID		81848	7016
HPRD ID		10466	03470
Ensembl ID		ENSG00000187678	ENSG00000107140
Uniprot IDs		A0A0C4DFS6 Q9C004	Q15569 Q8NFJ4
PDB IDs		3BUN
Enriched GO Terms of Interacting Partners?
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