CAMK2G and MRPL11

Data Source:
BioGRID (two hybrid)

		CAMK2G	MRPL11
Description		calcium/calmodulin dependent protein kinase II gamma	mitochondrial ribosomal protein L11
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Ribosome Mitochondrial Large Ribosomal Subunit Large Ribosomal Subunit
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding Large Ribosomal Subunit RRNA Binding
	Biological Process	Protein Phosphorylation Protein Dephosphorylation Nervous System Development Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Insulin Secretion Cell Differentiation Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Regulation Of Cellular Response To Heat	Translation Mitochondrial Translational Elongation Mitochondrial Translational Termination
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
Drugs		Bosutinib 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Fostamatinib
Diseases
GWAS		Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) FEV1 ( 30804560) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458)	Bipolar disorder ( 21926972) Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes		50 interacting genes: ACTN2 ACTN4 ADCY3 ATF1 CABP2 CALM1 CAMK2A CAMK2B CAMK2D CDC37 CHAT CREM DUS1L EGFR ESRRG FLNA GRIA1 GRIA4 GRIN1 GRIN2B KANK2 KRTAP19-3 KRTAP6-1 KRTAP6-3 LRRC7 MRPL11 MYLK NUTF2 NXF1 PEA15 PLCB3 PSMB1 PTEN RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 STRBP SYN1 TH TIAM1 TNPO2 TNPO3 TTC5 UBE2I	32 interacting genes: AGTRAP APP CAMK2A CAMK2B CAMK2D CAMK2G CCDC172 CRYAB ERCC6 FSD2 GOLGA6L9 HMBOX1 HOMEZ JAKMIP1 JAKMIP2 KRT40 MRPL54 MTUS2 PDCL PNMA1 SLC16A9 STX2 TAX1BP1 TFCP2 TFIP11 THAP1 VPS52 ZBTB14 ZBTB2 ZBTB8A ZNF438 ZNF526
Entrez ID		818	65003
HPRD ID		03672	14739
Ensembl ID		ENSG00000148660	ENSG00000174547
Uniprot IDs		A0A2Q3DQE3 B3KY86 Q13280 Q13555 Q5SWX3	Q9Y3B7
PDB IDs		2UX0 2V7O	3J7Y 3J9M 5OOL 5OOM 6I9R 6NU2 6NU3 6VLZ 6VMI 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG
Enriched GO Terms of Interacting Partners?
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