TRIM7 and BCAM

Data Source:
BioGRID (two hybrid)

		TRIM7	BCAM
Description		tripartite motif containing 7	basal cell adhesion molecule (Lutheran blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Transmembrane Signaling Receptor Activity Laminin Receptor Activity Protein Binding Protein C-terminus Binding Laminin Binding
	Biological Process	Protein Ubiquitination	Cell Adhesion Cell-matrix Adhesion Signal Transduction
Pathways
Drugs
Diseases
GWAS			Alzheimer's disease ( 30636644 24755620) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in hypertension ( 31055733) Alzheimer's disease in hypertension-negative individuals ( 31055733) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness (maximum) ( 31801372) Carotid intima media thickness (mean) ( 31801372) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 28247064 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 30275531) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321) Waist-to-hip circumference ratio (smoking years interaction) ( 23192594)
Interacting Genes		27 interacting genes: AQP1 BCAM CDK13 CFL2 CRYGC CTNNAL1 DES GTF2A2 GYG1 IRAK4 MAD2L2 NAA35 NABP1 OTUD6A RAB2A RIN1 RNASE1 RSPH14 RWDD2B SIAH1 SRC TP53I13 TRMT10A UBE2D1 UBE2D2 UBE2D3 UBE2E1	10 interacting genes: EPB41 KLHL2 KRTAP1-1 KRTAP1-3 LAMA5 MDFI NBPF19 NOTCH2NLA TRIM7 UBE2I
Entrez ID		81786	4059
HPRD ID		11648	00197
Ensembl ID		ENSG00000146054	ENSG00000187244
Uniprot IDs		Q9C029	A0A087WXM8 P50895
PDB IDs			2PET 2PF6
Enriched GO Terms of Interacting Partners?
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