TSC22D4 and MTHFS

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TSC22D4	MTHFS
Description		TSC22 domain family member 4	methenyltetrahydrofolate synthetase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Protein Binding	ATP Binding Folic Acid Binding 5-formyltetrahydrofolate Cyclo-ligase Activity Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Negative Regulation Of Transcription, DNA-templated	Glutamate Metabolic Process Folic Acid-containing Compound Biosynthetic Process Formate Metabolic Process Tetrahydrofolate Interconversion Tetrahydrofolate Metabolic Process Folic Acid Metabolic Process Folic Acid Catabolic Process
Pathways			Metabolism of folate and pterines
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Platelet count ( 27863252) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Blood protein levels ( 30072576 29875488) Cerebrospinal P-tau181p levels ( 28247064) Circulating leptin levels in high cardiovascular risk ( 31766143) Disease-free survival in breast cancer ( 25867717) Pars opercularis volume ( 31530798) Periodontitis (Mean PAL) ( 24024966) Response to fenofibrate (LDL cholesterol levels) ( 27002377)
Interacting Genes		63 interacting genes: ABLIM1 AIFM1 APIP ARHGAP9 BLZF1 CBX8 CCDC146 CCDC33 CCDC42 CCNK CDC23 CDK5R1 CKS2 CLU CTNNAL1 ENKD1 FBXW7 FRMD6 FXR2 GOLGA2 GORASP2 KPNA2 KRT40 LBP LMO1 LMO2 LNX1 LRP2BP MAD2L1 MTHFS MYLIP MYO15B NIF3L1 NOC4L NRBP1 NRBP2 PCBP1 PCDH17 PIH1D1 PIN1 POLR1C PPL PRKAA1 PRKAA2 PRNP PSMA1 RACK1 SACS SAT1 SMAD3 SMARCB1 SYT17 TEX11 TLE5 TRIM55 TRIM63 TSC22D1 TSPOAP1 UBLCP1 VBP1 ZBTB24 ZMYND10 ZNF580	1 interacting genes: TSC22D4
Entrez ID		81628	10588
HPRD ID		18231	09174
Ensembl ID		ENSG00000166925	ENSG00000136371
Uniprot IDs		B4DKI8 Q9Y3Q8	P49914
PDB IDs			3HXT 3HY3 3HY4 3HY6
Enriched GO Terms of Interacting Partners?
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