NPRL3 and FHL3

Data Source:
BioGRID (two hybrid)

		NPRL3	FHL3
Description		NPR3 like, GATOR1 complex subunit	four and a half LIM domains 3
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GO Annotations	Cellular Component	Lysosomal Membrane GATOR1 Complex	Stress Fiber Nucleus Focal Adhesion Z Disc
	Molecular Function	GTPase Activator Activity Protein Binding	Transcription Coregulator Activity Actin Binding Protein Binding Metal Ion Binding
	Biological Process	Ventricular Septum Development Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Aorta Morphogenesis TORC1 Signaling Positive Regulation Of GTPase Activity Cardiac Muscle Tissue Development Roof Of Mouth Development Regulation Of Autophagosome Assembly	Regulation Of Transcription, DNA-templated Muscle Organ Development Actin Cytoskeleton Organization
Pathways		Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Cardiometabolic and hematological traits ( 27668658) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693 26366553) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 29403010 32888494 28453575 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 28453575 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 29403010 32888494 27863252) Red blood cell traits ( 23446634 23222517) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Sickle cell anemia (haemolysis) ( 23406172)	Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)
Interacting Genes		3 interacting genes: APPBP2 FHL3 SESN3	181 interacting genes: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP ANKHD1 ARHGEF10 ARID5A ASCL4 BARX2 C1orf94 C9orf116 CASS4 CBX8 CCDC198 CCND3 CDC25B CDC42EP1 CDKN1A CDKN2D CHEK2 CLCN2 CNNM3 CNOT7 CORO1A CREB5 CRIP3 CRYBA2 CSF1 CTBP2 CYSRT1 DCDC2B DLGAP4 DMRT3 DUX4L9 E2F8 EFCAB12 EIF4EBP2 EPHA10 EPM2AIP1 ERBB3 EXOSC1 EXOSC5 FADS6 FAM110A FAM126A FAM222B FAM71C FAM90A1 FBXL18 FHL2 FOS FOSL2 FOXN4 GATA1 GATA2 GCM2 GUCD1 HAPLN2 HIPK1 HOXA1 HSF2BP HYAL2 IHO1 IKZF3 ITGA7 ITGB5 KANK2 KIDINS220 KIRREL2 KLF12 KLF3 KLF8 KPRP KRTAP12-1 KRTAP12-2 KTI12 LASP1 LATS2 LHB LMO2 LMO4 LNX1 LNX2 MAPK1 MED15 MMP14 MORF4L1 MPZL1 MRM3 MRPL27 MRRF MSRB3 MTA1 MTUS2 MYBPC1 MYBPHL MYOZ3 MYPOP MZF1 NDUFAB1 NFKBIB NPRL3 ODF3B P4HA2 PAK5 PATL1 PHC2 PHF21A PIAS1 PKP2 PLEKHF2 PLEKHG4B POLR1H PPIG PPP1R32 PRR35 PRR5L PTPN6 QKI QRICH1 RAB40B RAD21 RASL12 RBM42 RFX3 RFX6 RHEBL1 RSPH14 RYBP SAP30BP SAXO1 SBF2 SDCBP SH3GLB2 SHE SLAIN1 SLC25A46 SLC44A3 SLU7 SMAD2 SMAD3 SMAD4 SNRPB SNRPC SNRPG SPATA8 SREBF2 SRF SRGN SUPT5H TBC1D22B THAP7 THEG TLE5 TMEM108 TMEM14B TMSB4X TMX3 TOPBP1 TRAF3IP2 TRIM27 TRIP6 TRO TSGA10IP TTLL10 TUBA3E TYK2 TYMSOS UBE2I UBE2Q1 VWC2L WDR25 WNK1 YPEL3 ZCCHC14 ZFP36 ZNF417 ZNF512B ZNF587
Entrez ID		8131	2275
HPRD ID		11866	09101
Ensembl ID		ENSG00000103148	ENSG00000183386
Uniprot IDs		B7Z220 B7Z6Q0 Q12980 Q9BTE2	Q13643 Q96C98
PDB IDs		6CES 6CET	1WYH 2CUQ 2EHE
Enriched GO Terms of Interacting Partners?
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