TCL1A and CASP8AP2

Data Source:
BioGRID (two hybrid)

		TCL1A	CASP8AP2
Description		TCL1 family AKT coactivator A	caspase 8 associated protein 2
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GO Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Cytosol Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Mitochondrion PML Body
	Molecular Function	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity	Transcription Corepressor Activity Death Receptor Binding Protein Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Peptidase Activator Activity Involved In Apoptotic Process SUMO Polymer Binding
	Biological Process	Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Serine/threonine Kinase Activity	Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Fas Signaling Pathway Negative Regulation Of Transcription, DNA-templated Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway
Pathways			SUMOylation of transcription cofactors
Drugs
Diseases
GWAS		Adverse response to aromatase inhibitors ( 20876420) Mosaic loss of chromosome Y ( 27064253) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Plateletcrit ( 32888494) Refractive error ( 32231278)	Asthma ( 31959851) Estimated glomerular filtration rate in non-diabetics ( 31451708) Major depressive disorder ( 29317602)
Interacting Genes		38 interacting genes: AKT1 AKT2 AKT3 ATM CADPS CALCOCO2 CARD9 CASP8AP2 CCDC13 CEP55 DDIT4L DNMT3A FLACC1 GOLGA2 H2AW INCA1 LNX1 LNX2 LSM3 NFKBIA NFKBID NIF3L1 NTAQ1 PPP1R13B PRTFDC1 REL TAX1BP1 TCF4 TEPSIN TNKS TP53BP2 TRAF1 TRAF2 TRMT61A TTC33 TXLNA TXLNB WDR47	19 interacting genes: CALM1 CASP10 CASP8 CREBBP CREM CTBP2 FADD FAS GLUL MX1 NAA10 NR3C2 PML SP100 SREBF2 TCL1A TRAF2 TRIM21 UBE2I
Entrez ID		8115	9994
HPRD ID		01744	06048
Ensembl ID		ENSG00000100721	ENSG00000118412
Uniprot IDs		A0A024R6G5 P56279	Q9UKL3
PDB IDs		1JSG	2LR8 6ANO 6AOZ 6AP0
Enriched GO Terms of Interacting Partners?
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