CYB5B and NDUFAF2

Data Source:
BioGRID (two hybrid)

		CYB5B	NDUFAF2
Description		cytochrome b5 type B	NADH:ubiquinone oxidoreductase complex assembly factor 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrial Outer Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Nitric-oxide Synthase Complex	Mitochondrion Mitochondrial Inner Membrane
	Molecular Function	Protein Binding Enzyme Activator Activity Electron Transfer Activity Heme Binding Metal Ion Binding Nitrite Reductase (NO-forming) Activity	Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Protein-containing Complex Binding
	Biological Process	Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Electron Transport Chain Regulation Of Catalytic Activity	Electron Transport Chain Mitochondrial Respiratory Chain Complex I Assembly
Pathways		Phase I - Functionalization of compounds	Complex I biogenesis
Drugs		Phenethyl Isothiocyanate
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Blood osmolality (transformed sodium) ( 28360221) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Heel bone mineral density ( 30598549) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Serum uric acid levels ( 30993211 29403010)	Autism spectrum disorder or schizophrenia ( 28540026) Brain morphology (MOSTest) ( 32665545) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (MOSTest) ( 32665545) Household income ( 31844048) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Parkinson's disease ( 27182965) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		48 interacting genes: AHNAK2 APP AQP6 BIK BNIP3L BTNL9 CD33 CD79A CGRRF1 CLDN7 CLN8 CPLX4 CREB3 EBP FAM209A FAM210B FNDC9 FRMD3 GJB5 GPR152 IGSF9 KCNK5 KIR2DL3 LMNA MARCHF8 MFF MFSD14B MFSD4B MFSD5 MUC1 NDUFAF2 PDZK1IP1 PHACTR3 PLPP4 REEP4 RETREG3 SDHAF4 SLC10A6 SLC16A2 SLC39A9 STOM STX1A SYT1 TMEM139 TMEM237 TMEM35A TMEM41A TMEM86B	9 interacting genes: CYB5B LAT LPAR3 SEC22B SMIM1 SPG21 STX8 TMEM201 TMEM97
Entrez ID		80777	91942
HPRD ID		13106	14288
Ensembl ID		ENSG00000103018	ENSG00000164182
Uniprot IDs		O43169	A0A0S2Z5U1 Q8N183
PDB IDs		3NER
Enriched GO Terms of Interacting Partners?
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