FLAD1 and APTX

Data Source:
BioGRID (two hybrid)

		FLAD1	APTX
Description		flavin adenine dinucleotide synthetase 1	aprataxin
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Matrix Cytosol Plasma Membrane	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	FMN Adenylyltransferase Activity Protein Binding ATP Binding Identical Protein Binding	Chromatin Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Double-stranded RNA Binding Protein Binding Phosphoglycolate Phosphatase Activity Mismatched DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Metal Ion Binding Protein N-terminus Binding Phosphoprotein Binding Single-strand Break-containing DNA Binding
	Biological Process	FAD Biosynthetic Process Riboflavin Metabolic Process	Single Strand Break Repair DNA Ligation Double-strand Break Repair Cellular Response To DNA Damage Stimulus Dephosphorylation Regulation Of Protein Stability Response To Hydrogen Peroxide Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Vitamin B2 (riboflavin) metabolism
Drugs
Diseases			Coenzyme Q10 deficiency Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Prostate cancer ( 23535732) Red blood cell count ( 32888494) Refractive error ( 32231278)	Height ( 28552196) Menopause (age at onset) ( 26414677)
Interacting Genes		20 interacting genes: ANXA7 APTX CDKN1A CLVS2 COPS3 CRABP2 DNM2 GEMIN4 GRB7 L3MBTL3 NIF3L1 NUDT21 PRTFDC1 RCC1 REL SDCBP SMN1 TCF4 TK1 TRIM23	18 interacting genes: CALCOCO1 CEP350 CNTROB FLAD1 HIVEP1 MAPKBP1 MBP PARP1 PICK1 PNMA1 PNMA3 SYT17 TP53 TRIM37 TSPYL2 XRCC1 XRCC4 ZNF639
Entrez ID		80308	54840
HPRD ID		17887	05892
Ensembl ID		ENSG00000160688	ENSG00000137074
Uniprot IDs		Q8NFF5	Q7Z2E3
PDB IDs			3KT9 4NDF 4NDG 4NDH 4NDI 6CVO 6CVP 6CVQ 6CVR 6CVS 6CVT
Enriched GO Terms of Interacting Partners?
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