SPSB1 and VWA5A

Data Source:
BioGRID (two hybrid)

		SPSB1	VWA5A
Description		splA/ryanodine receptor domain and SOCS box containing 1	von Willebrand factor A domain containing 5A
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol SCF Ubiquitin Ligase Complex	Nucleoplasm
	Molecular Function	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Cognitive function ( 28093568) Dental caries ( 23064961) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Height ( 28552196 31562340) Immune response to anthrax vaccine ( 22658931) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Pulse pressure ( 27841878 30578418) Response to tocilizumab in rheumatoid arthritis ( 22491018) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418)	Aging (time to death) ( 21782286)
Interacting Genes		14 interacting genes: ADPRH ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1 TRIM55 TRIM63 VWA5A	6 interacting genes: APP MEOX2 PPARA PRTFDC1 RHOU SPSB1
Entrez ID		80176	4013
HPRD ID		18106	04238
Ensembl ID		ENSG00000171621	ENSG00000110002
Uniprot IDs		A0A024R4G8 Q96BD6	A0A024R3H3 O00534
PDB IDs		2JK9 3F2O
Enriched GO Terms of Interacting Partners?
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