CTC1 and TPP1

Data Source:
BioGRID (affinity chromatography technology, pull down)

		CTC1	TPP1
Description		CST telomere replication complex component 1	tripeptidyl peptidase 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol CST Complex	Lysosome Golgi Apparatus Melanosome Lysosomal Lumen Membrane Raft Recycling Endosome Extracellular Exosome
	Molecular Function	Single-stranded DNA Binding Protein Binding Telomeric DNA Binding G-rich Strand Telomeric DNA Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Tripeptidyl-peptidase Activity Lysophosphatidic Acid Binding Peptide Binding Metal Ion Binding Sulfatide Binding
	Biological Process	Telomere Maintenance Cellular Response To DNA Damage Stimulus Regulation Of G2/M Transition Of Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomerase Multicellular Organism Growth Positive Regulation Of DNA Replication Positive Regulation Of Fibroblast Proliferation Spleen Development Thymus Development Bone Marrow Development Hematopoietic Stem Cell Proliferation Replicative Senescence	Proteolysis Lipid Metabolic Process Lysosome Organization Nervous System Development Central Nervous System Development Protein Catabolic Process Epithelial Cell Differentiation IRE1-mediated Unfolded Protein Response Peptide Catabolic Process Bone Resorption Neuromuscular Process Controlling Balance Protein Localization To Chromosome, Telomeric Region Lysosomal Protein Catabolic Process
Pathways		Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation	XBP1(S) activates chaperone genes
Drugs
Diseases			Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Bipolar disorder ( 28115744) Telomere length ( 23001564)	Malaria ( 31844061)
Interacting Genes		2 interacting genes: APPBP2 TPP1	6 interacting genes: CTC1 NMB POT1 STN1 TERT TINF2
Entrez ID		80169	1200
HPRD ID		07980	06415
Ensembl ID		ENSG00000178971	ENSG00000166340
Uniprot IDs		Q2NKJ3	O14773
PDB IDs		5W2L 6W6W	1R60 3EDY 3EE6
Enriched GO Terms of Interacting Partners?
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