TRIM46 and OTUD6A

Data Source:
BioGRID (two hybrid)

		TRIM46	OTUD6A
Description		tripartite motif containing 46	OTU deubiquitinase 6A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoskeleton Axon Initial Segment Main Axon Axon Cytoplasm Proximal Neuron Projection
	Molecular Function	Zinc Ion Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	Microtubule Bundle Formation Neuron Migration Axonogenesis Negative Regulation Of Axon Extension Anterograde Synaptic Vesicle Transport Protein Localization To Axon Positive Regulation Of Anterograde Dense Core Granule Transport Regulation Of Cellular Protein Localization	Protein Deubiquitination Protein Phosphopantetheinylation Protein K29-linked Deubiquitination Protein K11-linked Deubiquitination Protein K27-linked Deubiquitination Protein K33-linked Deubiquitination
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Breast cancer ( 29059683) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Microalbuminuria ( 31511532) Serum uric acid levels ( 30993211) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31985003 31578528 23263486) Urinary albumin-to-creatinine ratio ( 31511532) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		20 interacting genes: AK5 APP BRCA1 CBLC MDM4 MTNR1B OTUD6A RNF125 RNF7 TK1 TRIM9 TSG101 UBE2D2 UBE2U UBE2Z UCHL5 USP1 USP15 USP2 USP32	18 interacting genes: CBLC DPYSL3 DYNLL1 DYNLL2 EMX2 MYCL NUP62 PDLIM7 POM121 RBCK1 RNF2 SSBP1 TRIM39 TRIM46 TRIM5 TRIM7 UBC VPS52
Entrez ID		80128	139562
HPRD ID		15563	13681
Ensembl ID		ENSG00000163462	ENSG00000189401
Uniprot IDs		A0A087WUH1 B7Z4F9 F5GYK0 Q7Z4K8	Q7L8S5
PDB IDs
Enriched GO Terms of Interacting Partners?
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