PHC3 and OGT

Data Source:
BioGRID (two hybrid)

		PHC3	OGT
Description		polyhomeotic homolog 3	O-linked N-acetylglucosamine (GlcNAc) transferase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytosol Plasma Membrane Protein N-acetylglucosaminyltransferase Complex Mitochondrial Membrane Protein-containing Complex Cell Projection
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Acetylglucosaminyltransferase Activity Protein N-acetylglucosaminyltransferase Activity Protein O-GlcNAc Transferase Activity
	Biological Process	Multicellular Organism Development Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition	Regulation Of Glycolytic Process Regulation Of Gluconeogenesis Regulation Of Transcription By RNA Polymerase II Protein O-linked Glycosylation Apoptotic Process Signal Transduction Response To Nutrient Viral Process Protein Processing Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Rac Protein Signal Transduction Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Proteolysis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Histone H3-K27 Methylation Histone H3-K4 Trimethylation Positive Regulation Of Cold-induced Thermogenesis
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Red cell distribution width ( 32888494)
Interacting Genes		4 interacting genes: AGR2 H3-4 HYPK OGT	28 interacting genes: CSNK2A1 CSNK2B GSK3B HCFC1 HIRA HIVEP1 MAPT MTDH NUP62 NUP62CL OGA PHC3 PSG1 SAP30BP SCAI SIN3A SNAP91 SP1 SRF TAB1 TAB3 TET2 TRAF7 TRAK1 TRAK2 UBC YES1 ZNF124
Entrez ID		80012	8473
HPRD ID		10149	02222
Ensembl ID		ENSG00000173889	ENSG00000147162
Uniprot IDs		B4E2T1 E7EX82 Q8NDX5	O15294
PDB IDs		4PZN 4PZO	1W3B 3PE3 3PE4 3TAX 4AY5 4AY6 4CDR 4GYW 4GYY 4GZ3 4GZ5 4GZ6 4N39 4N3A 4N3B 4N3C 4XI9 4XIF 5BNW 5C1D 5HGV 5LVV 5LWV 5NPR 5NPS 5VIE 5VIF 6E37 6EOU 6IBO 6MA1 6MA2 6MA3 6MA4 6MA5 6Q4M 6TKA
Enriched GO Terms of Interacting Partners?
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