DOK3 and A1CF

Data Source:
BioGRID (two hybrid)

		DOK3	A1CF
Description		docking protein 3	APOBEC1 complementation factor
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Secretory Granule Membrane Ficolin-1-rich Granule Membrane	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Apolipoprotein B MRNA Editing Enzyme Complex
	Molecular Function	Protein Binding	RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding
	Biological Process	Neutrophil Degranulation	MRNA Processing Cytidine To Uridine Editing MRNA Modification Protein Stabilization
Pathways		Neutrophil degranulation	mRNA Editing: C to U Conversion Formation of the Editosome
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Inflammatory bowel disease ( 23128233) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Colorectal cancer or advanced adenoma ( 30510241) Estimated glomerular filtration rate ( 31152163 31015462 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Interferon alpha levels in systemic lupus erythematosus ( 25338677) LDL cholesterol ( 30275531) Low density lipoprotein cholesterol levels ( 32154731) Narcolepsy with cataplexy ( 25986216) Serum uric acid levels ( 30993211) Total cholesterol levels ( 30275531) Triglyceride levels ( 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 30275531) Urate levels ( 31985003 31578528 23263486) Urate levels in lean individuals ( 25811787)
Interacting Genes		31 interacting genes: A1CF ABL1 ANKS1A APPL1 APPL2 COX5B CRK CSK DOK1 DOK2 DOK5 DTX2 FYN GCM2 HOXA1 INPP5D LCK LYN MDFI PLEKHA3 PPIH PRKAB2 RBPMS RET RIN3 SHC3 SHE SPAG8 STAT3 TNS2 TRAF1	26 interacting genes: APOBEC1 C19orf54 C9orf24 CAVIN2 CELF2 CYSRT1 DOK3 ECM1 EIF4G1 FHL2 FHL3 HSPB2 HSPB2-C11orf52 KHSRP KLHDC7B KRT31 KRT34 METTL27 OIP5 PLEKHG4 POGZ REL RIMBP3C SYNCRIP TNPO2 TRAF1
Entrez ID		79930	29974
HPRD ID		16834	10627
Ensembl ID		ENSG00000146094	ENSG00000148584
Uniprot IDs		A0A024R7M5 A0A6M4C8X9 D6RAM3 Q7L591	A0A024QZI9 A0A024QZJ5 A0A024QZM7 B4E1E3 F8W9F8 Q9NQ94
PDB IDs			2CPD
Enriched GO Terms of Interacting Partners?
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