CALCR and RAMP1

Data Source:
HPRD (in vitro)

		CALCR	RAMP1
Description		calcitonin receptor	receptor activity modifying protein 1
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Axon Amylin Receptor Complex 1 Amylin Receptor Complex 2 Amylin Receptor Complex 3	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex Amylin Receptor Complex 1 CGRP Receptor Complex
	Molecular Function	Amyloid-beta Binding Calcitonin Gene-related Peptide Receptor Activity Calcitonin Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Calcitonin Binding Amylin Receptor Activity	Calcitonin Gene-related Peptide Receptor Activity Protein Binding Coreceptor Activity Amylin Receptor Activity Calcitonin Gene-related Peptide Binding
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Gene Expression Positive Regulation Of Protein Kinase A Signaling Positive Regulation Of Cell Death Positive Regulation Of Peptidyl-serine Phosphorylation Cross-receptor Inhibition Within G Protein-coupled Receptor Heterodimer Response To Glucocorticoid Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of ERK1 And ERK2 Cascade Amylin Receptor Signaling Pathway Response To Amyloid-beta Positive Regulation Of Calcium Ion Import Across Plasma Membrane	Angiogenesis Calcium Ion Transport Intracellular Protein Transport G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Transport Receptor Internalization Positive Regulation Of Protein Binding Cellular Response To Hormone Stimulus Positive Regulation Of Protein Glycosylation Protein Localization To Plasma Membrane Amylin Receptor Signaling Pathway Calcitonin Gene-related Peptide Receptor Signaling Pathway
Pathways		G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		Salmon calcitonin Pramlintide	Pramlintide
Diseases
GWAS		Birth weight ( 23202124) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 28892062 25760438 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Hip circumference ( 28552196 25673412) Lean body mass ( 28552196 28724990) Type 2 diabetes ( 32499647) Weight ( 28552196)	Obesity-related traits ( 23251661) Resting metabolic rate ( 28476931)
Interacting Genes		9 interacting genes: CALM1 FLNA GPRASP1 GPRASP2 MBL2 RAMP1 RAMP3 SQSTM1 THBS1	9 interacting genes: CALCA CALCR CALCRL IAPP MAL MS4A13 NKG7 SLC31A2 VIPR1
Entrez ID		799	10267
HPRD ID		00239	05515
Ensembl ID		ENSG00000004948	ENSG00000132329
Uniprot IDs		A0A0C4DG16 P30988	E9PC20 O60894
PDB IDs		5II0 5UZ7 6NIY 6PFO 6PGQ	2YX8 3N7P 3N7R 3N7S 4RWG 5V6Y 6D1U 6E3Y 6UMG 6ZHO 6ZIS
Enriched GO Terms of Interacting Partners?
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