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NEIL1 and XRCC1
Data Source:
HPRD
(in vitro)
NEIL1
XRCC1
Description
nei like DNA glycosylase 1
X-ray repair cross complementing 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Microtubule Organizing Center
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Nucleolus
ERCC4-ERCC1 Complex
Molecular Function
Damaged DNA Binding
DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Protein C-terminus Binding
Zinc Ion Binding
Hydrolase Activity, Acting On Glycosyl Bonds
DNA N-glycosylase Activity
Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Protein Binding
Enzyme Binding
Oxidized DNA Binding
3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity
Biological Process
Base-excision Repair
Response To Oxidative Stress
Negative Regulation Of Nuclease Activity
Depyrimidination
Single Strand Break Repair
Double-strand Break Repair Via Homologous Recombination
Response To Hypoxia
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Base-excision Repair, DNA Ligation
Nucleotide-excision Repair, DNA Gap Filling
Double-strand Break Repair Via Nonhomologous End Joining
Response To Organic Substance
Negative Regulation Of Protein ADP-ribosylation
Cerebellum Morphogenesis
Hippocampus Development
Response To Hydroperoxide
Response To Drug
Voluntary Musculoskeletal Movement
Telomeric DNA-containing Double Minutes Formation
Positive Regulation Of Single Strand Break Repair
Positive Regulation Of DNA Ligase Activity
Negative Regulation Of Protection From Non-homologous End Joining At Telomere
Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Defective Base Excision Repair Associated with NEIL1
Resolution of AP sites via the single-nucleotide replacement pathway
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
HDR through MMEJ (alt-NHEJ)
Gap-filling DNA repair synthesis and ligation in GG-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs
Iron
Copper
Ferrous gluconate
Ferrous succinate
Ferrous ascorbate
Ferrous fumarate
Ferrous glycine sulfate
Diseases
GWAS
Apolipoprotein B levels (
32203549
)
Height (
31562340
)
LDL cholesterol levels (
32203549
)
Low density lipoprotein cholesterol levels (
32154731
)
Plasma amyloid beta peptide concentrations (ABx-42) (
24535457
)
Interacting Genes
6 interacting genes:
APP
HUS1
LIG3
POLB
RAD1
XRCC1
18 interacting genes:
APEX1
APLF
APTX
BRCA1
BTRC
CSNK2A1
CSNK2A2
LIG3
NEIL1
OGG1
PARP1
PARP2
PCNA
PNKP
POLB
RNF146
TOPORS
UBE2I
Entrez ID
79661
7515
HPRD ID
12314
01909
Ensembl ID
ENSG00000140398
ENSG00000073050
Uniprot IDs
Q96FI4
B2RCY5
P18887
Q59HH7
PDB IDs
1TDH
4NRV
5ITQ
5ITR
5ITT
5ITU
5ITX
5ITY
1CDZ
1XNA
1XNT
2D8M
2W3O
3K75
3K77
3LQC
5E6Q
5W7X
5W7Y
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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