ABHD16A and PTGS2

Data Source:
HPRD (two hybrid)

		ABHD16A	PTGS2
Description		abhydrolase domain containing 16A, phospholipase	prostaglandin-endoperoxide synthase 2
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Integral Component Of Membrane	Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Neuron Projection
	Molecular Function	Phospholipase Activity Lysophospholipase Activity Protein Binding Palmitoyl-(protein) Hydrolase Activity Acylglycerol Lipase Activity	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Enzyme Binding Heme Binding Metal Ion Binding Dioxygenase Activity
	Biological Process	Phosphatidylserine Catabolic Process Protein Phosphopantetheinylation Monoacylglycerol Catabolic Process Macromolecule Depalmitoylation Prostaglandin Catabolic Process	Prostaglandin Biosynthetic Process Inflammatory Response Response To Oxidative Stress Regulation Of Blood Pressure Positive Regulation Of Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Cyclooxygenase Pathway Lipoxygenase Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Long-chain Fatty Acid Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Inflammatory Response Cellular Response To Hypoxia Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Fibroblast Growth Factor Production Positive Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Platelet-derived Growth Factor Production Cellular Oxidant Detoxification Regulation Of Neuroinflammatory Response
Pathways			Nicotinamide salvaging Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic Ï‰-3 PUFA oxo-derivatives
Drugs			Dihomo-gamma-linolenic acid Icosapent Aminosalicylic acid Mesalazine Acetaminophen Indomethacin Nabumetone Ketorolac Tenoxicam Lenalidomide Celecoxib Tolmetin Rofecoxib Piroxicam Fenoprofen Valdecoxib Diclofenac Sulindac Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Thalidomide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Ginseng Antrafenine Antipyrine Tiaprofenic acid Etoricoxib Flufenamic acid Resveratrol 1-Phenylsulfonamide-3-Trifluoromethyl-5-Parabromophenylpyrazole Prostaglandin G2 Niflumic acid Licofelone Nimesulide Cimicoxib Lornoxicam Aceclofenac Nepafenac Parecoxib Pomalidomide Cannabidiol Loxoprofen Dexibuprofen Dexketoprofen Droxicam Tolfenamic acid Firocoxib Morniflumate Propacetamol Talniflumate Phenyl salicylate Trolamine salicylate Menthyl salicylate Glycol salicylate Dipyrithione Bryostatin 1 Alclofenac Bufexamac Bendazac Acemetacin Fish oil Medical Cannabis Nabiximols
Diseases			Esophageal cancer Cholangiocarcinoma Penile cancer
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Monocyte percentage of white cells ( 32888494) Ulcerative colitis ( 28067908)	Crohn's disease ( 26192919) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798)
Interacting Genes		69 interacting genes: AGPAT3 AQP6 AQP7 ATP5MC3 ATP5PF BRI3 CBARP CIDEB CREB3 CYP1A2 DNAJC1 DTX2 EBP ERGIC3 FDPS FKBP7 GDAP1 GJA5 GOLT1A GORAB GPR152 GPRC5C GYPC HM13 HNRNPA1 HSD17B13 IFITM1 IFITM3 ITGAM LTA MLH1 MT-ND3 MT-ND4 PERP PILRB PKMYT1 POLE PRAF2 PTGS2 RETREG3 RHBDD2 RHBDL1 RNF5 SAFB SEC22B SERF1A SERF1B SLC10A1 SLC30A2 SLC7A8 SPAG4 SPAG7 STMN4 STX1B TM4SF19 TMEM139 TMEM143 TMEM147 TMEM14B TMEM222 TMEM237 TMEM31 TMEM65 TSPAN2 UNC93A UPF1 VAMP5 VMA21 WBP1L	13 interacting genes: ABHD16A CASK CAV1 CELF2 COPS5 COPS7A CTNNB1 ELAVL1 GAS5 NUCB1 PTGIS TP53 USP22
Entrez ID		7920	5743
HPRD ID		15929	02599
Ensembl ID		ENSG00000204427	ENSG00000073756
Uniprot IDs		A0A1U9X777 B3KNX9 O95870	P35354
PDB IDs			1V0X 5F19 5F1A 5IKQ 5IKR 5IKT 5IKV 5KIR
Enriched GO Terms of Interacting Partners?
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