DDX39B and CHTOP

Data Source:
BioGRID (two hybrid, proximity labelling technology)

		DDX39B	CHTOP
Description		DExD-box helicase 39B	chromatin target of PRMT1
Image			No pdb structure
GO Annotations	Cellular Component	Transcription Export Complex Nucleus Nucleoplasm Spliceosomal Complex U4 SnRNP U6 SnRNP Cytoplasm Nuclear Matrix Nuclear Speck	Transcription Export Complex Nucleoplasm Nucleolus Nuclear Speck Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	RNA Binding RNA Helicase Activity Protein Binding ATP Binding RNA-dependent ATPase Activity ATPase Activity U6 SnRNA Binding U4 SnRNA Binding Identical Protein Binding ATP-dependent Protein Binding Protein-containing Complex Binding	RNA Binding Protein Binding Methyl-CpG Binding
	Biological Process	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome Liver Development RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing RNA Secondary Structure Unwinding MRNA 3'-end Processing Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Translation Viral MRNA Export From Host Cell Nucleus Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of DNA Damage Checkpoint Positive Regulation Of DNA Biosynthetic Process	In Utero Embryonic Development RNA Export From Nucleus MRNA Export From Nucleus Positive Regulation Of Cell Population Proliferation Positive Regulation Of Histone Methylation MRNA 3'-end Processing Positive Regulation Of ATPase Activity Positive Regulation Of Helicase Activity
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs		Artenimol
Diseases
GWAS		Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) High light scatter reticulocyte count ( 32888494) Inflammatory bowel disease ( 28067908) Malaria ( 31844061) Mean platelet volume ( 27863252) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 27863252) Mosquito bite size ( 28199695) Myositis ( 26291516) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		31 interacting genes: ALYREF BARD1 CHTOP DDX39A DNM2 EXOSC9 FANCA HIPK2 HNRNPLL IL7R LUZP4 NCBP2 PIAS2 RBM39 RNF4 RPS15A SARNP SDCBP SNRPA SREK1 SRPK2 STRN4 SUMO2 TDG THOC3 THOC6 TUBB3 U2AF2 UBE2I YWHAG ZHX1	12 interacting genes: APOBEC3C APP DDX39A DDX39B ERH KHDRBS2 PHLDB3 RBM3 SMN1 SMN2 SNRPA SRPK2
Entrez ID		7919	26097
HPRD ID		00805	13163
Ensembl ID		ENSG00000198563	ENSG00000160679
Uniprot IDs		A0A024RCM3 Q13838	A0A087X1B7 Q9Y3Y2
PDB IDs		1T5I 1T6N 1XTI 1XTJ 1XTK
Enriched GO Terms of Interacting Partners?
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