FTO and MAD2L2

Data Source:
BioGRID (two hybrid)

		FTO	MAD2L2
Description		FTO alpha-ketoglutarate dependent dioxygenase	mitotic arrest deficient 2 like 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Speck Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Anaphase-promoting Complex Chromosome Nucleolus Spindle Cytosol Zeta DNA Polymerase Complex Site Of Double-strand Break
	Molecular Function	Ferrous Iron Binding Transferase Activity Oxidative RNA Demethylase Activity Oxidative DNA Demethylase Activity DNA-N1-methyladenine Dioxygenase Activity RNA N6-methyladenosine Dioxygenase Activity TRNA Demethylase Activity	RNA Polymerase II Activating Transcription Factor Binding Protein Binding JUN Kinase Binding
	Biological Process	DNA Dealkylation Involved In DNA Repair Regulation Of Lipid Storage Oxidative Single-stranded DNA Demethylation Oxidative Single-stranded RNA Demethylation Regulation Of Multicellular Organism Growth RNA Repair MRNA Destabilization Oxidative Demethylation DNA Demethylation Regulation Of Brown Fat Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Double-strand Break Repair Actin Filament Organization Mitotic Spindle Assembly Checkpoint Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription By Competitive Promoter Binding Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Protein Catabolic Process Error-prone Translesion Synthesis DNA Damage Response, Signal Transduction Resulting In Transcription Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Isotype Switching Positive Regulation Of Transcription, DNA-templated Cell Division Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Ubiquitin Protein Ligase Activity Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		Reversal of alkylation damage by DNA dioxygenases	Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI
Drugs		Artenimol
Diseases		Growth retardation, developmental delay, coarse facies, and early death Type II diabetes mellitus
GWAS		Adiposity ( 21706003) Adolescent idiopathic scoliosis ( 31417091) Adult body size ( 32376654) Age at adiposity rebound ( 31840077) Alcohol consumption ( 31358974) Alcohol consumption (heavy vs. light/non-drinkers) ( 31998841) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813) Allergic rhinitis ( 25085501) Basal metabolic rate ( 31453325) Basal metabolic rate variance ( 31453325) Beef consumption ( 32066663) Biomedical quantitative traits ( 19396169) Blood glucose levels ( 31928498) Blood urea nitrogen levels ( 31152163 29403010) BMI (adjusted for smoking behaviour) ( 28443625) BMI at 7 years old ( 31575865) BMI at 8 years old ( 31575865) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Body fat percentage ( 26833246 28270201 31453325) Body fat percentage variance ( 31453325) Body mass in chronic obstructive pulmonary disease ( 21037115) Body mass index ( 28552196 31513605 29381148 31888951 30045251 24064335 22982992 23563607 26426971 19079260 19079261 26961502 24348519 23669352 24861553 28270201 18454148 31453325 28892062 25673413 20935630 23583978 28448500 17434869 25953783) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age interaction) ( 25953783) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index (SNP x SNP interaction) ( 22344221) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Breast cancer ( 29059683 23535729 23535733 27117709) Breast cancer (estrogen-receptor negative) ( 27117709 29058716) Breast size ( 27182965) C-reactive protein levels ( 30388399) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) Childhood body mass index ( 33045005 26604143) Chromosomal aberration frequency (chromosome type) ( 31586183) Chronotype ( 30696823) circulating leptin levels ( 32917775 26833098) Coffee consumption ( 31046077) Cutaneous malignant melanoma ( 32341527) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Dietary macronutrient intake ( 23636237 29988085) End-stage kidney disease ( 31178898) Eyebrow thickness ( 26926045) Facial morphology ( 31763980) Fish- and plant-related diet ( 32066663) Glycated hemoglobin levels ( 28898252) Hand grip strength ( 29691431) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 32203549 28334899) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Heart failure ( 31919418) Heel bone mineral density ( 30598549 28869591) Height adjusted BMI ( 25044758) High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference ( 28552196 31453325 25673412) Hip circumference variance ( 31453325) Intake of total sugars ( 31005972) LDL cholesterol levels ( 32203549) Lean body mass ( 28552196 28724990) Lung function (FEV1/FVC) ( 30804560) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Melanoma ( 28212542 23455637) Menarche (age at onset) ( 27182965 21102462 25231870) Metabolic syndrome ( 22399527 31589552) Morning person ( 30696823) Nevus count or cutaneous melanoma ( 32341527 30429480) Non-oily fish consumption ( 32066663) Number of sexual partners ( 30643258) Obese vs. thin ( 30677029) Obesity ( 23563607 19151714 21544081 21552555) Obesity (early onset extreme) ( 20421936 23563609 18159244) Obesity (extreme) ( 30677029 31852448 19553259) Obesity-related traits ( 17658951) Oily fish consumption ( 32066663) Osteoarthritis ( 22763110) Pork consumption ( 32066663) Problematic alcohol use ( 32451486) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Pure non-grapefruit juice consumption ( 31046077) Red cell distribution width ( 28957414) Red vs. brown/black hair color ( 30531825) Relative sugar intake ( 32393786) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Sasang constitutional medicine type (So-Eum) ( 25888059) Sex hormone-binding globulin levels ( 22675492) Sleep duration (long sleep) ( 30846698) Strenuous sports or other exercises ( 29899525) Subcutaneous adipose tissue ( 22589738 27918534) Subscapular skin fold thickness ( 31513605) Sugar-sweetened beverage consumption ( 31046077) Sweet beverage consumption ( 31046077) Systolic blood pressure ( 31928498) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Thiopurine-induced leukopenia in inflammatory bowel disease ( 27558924) Triglyceride levels ( 28334899) Triglycerides ( 24097068 30275531) Trunk fat mass ( 28552196) Type 2 diabetes ( 22885922 18372903 24509480 30054458 22693455 26961502 30297969 17554300 26818947 32499647 20581827 30718926 17463248 17463249 28869590 19056611 23209189) Type 2 diabetes nephropathy ( 30566433) Type 2 diabetes nephropathy including microalbuminuria ( 30566433) Urate levels ( 31578528) Urinary sodium excretion ( 31409800) Urolithiasis ( 30975718) Waist circumference ( 28552196 19557197 31453325 31928498 25673412) Waist circumference variance ( 31453325) Waist-hip ratio ( 28552196 25673412) Weight ( 28552196 19079260)	Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		19 interacting genes: ANKRD11 C1orf109 CCDC57 CLP1 DTX2 EFEMP2 GNG13 GPANK1 IL16 KLHL38 MAD2L2 MORN3 NXF1 PRDM6 SHC3 TNPO2 TTC19 USP20 ZNF77	47 interacting genes: ADAM15 ADAM17 ADAM9 C20orf85 CAMK2B CDC20 CDH1 DEPDC5 ELK1 FAM217B FTO FZR1 GSC2 IKZF1 IKZF3 INCA1 KCTD9 KRT34 MAD2L1 MAD2L1BP MBD3L1 MYBPC2 PLAGL2 POLDIP2 PPM1B PRCC PRR5L PRRC2A RAB11FIP4 RBBP6 REL REV1 REV3L SFI1 SHLD1 TCF4 THAP6 TRIM27 TRIM54 TRIM7 YPEL3 YY1AP1 ZBED1 ZMYND12 ZNF511 ZNF558 ZNF655
Entrez ID		79068	10459
HPRD ID		19057	07246
Ensembl ID		ENSG00000140718	ENSG00000116670
Uniprot IDs		A0A1B0GTC5 B3KU60 Q99770 Q9C0B1	A0A024R4I4 Q9UI95
PDB IDs		3LFM 4CXW 4CXX 4CXY 4IDZ 4IE0 4IE4 4IE5 4IE6 4IE7 4QHO 4QKN 4ZS2 4ZS3 5DAB 5F8P 5ZMD 6AEJ 6AK4 6AKW	3ABD 3ABE 3VU7 4EXT 4GK0 4GK5 5XPT 5XPU 6BC8 6BCD 6BI7 6K07 6K08 6KEA 6KTO 6NIF
Enriched GO Terms of Interacting Partners?
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