NOC4L and NT5C2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NOC4L	NT5C2
Description		nucleolar complex associated 4 homolog	5'-nucleotidase, cytosolic II
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Integral Component Of Membrane Noc4p-Nop14p Complex Nuclear Membrane Small-subunit Processome	Cytosol
	Molecular Function	RNA Binding Protein Binding	Nucleotide Binding Protein Binding 5'-nucleotidase Activity Metal Ion Binding
	Biological Process	RRNA Processing	Purine Nucleotide Catabolic Process Dephosphorylation Drug Metabolic Process IMP Metabolic Process Adenosine Metabolic Process
Pathways		rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol	Abacavir metabolism Purine catabolism
Drugs			ATP Taribavirin
Diseases
GWAS		Body mass index ( 26426971) Hirschsprung disease ( 26887379) Response to antidepressants (symptom improvement) ( 29160301) Response to SSRI (symptom remission) ( 29160301)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Birth weight ( 31043758 27680694) Blood pressure ( 21572416 24001895 21909110) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 29381148 24861553 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Coronary artery disease ( 32469254 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Diastolic blood pressure ( 28739976 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertension ( 31879980 30487518) Immature fraction of reticulocytes ( 32888494) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intracranial aneurysm ( 33199917) Mean arterial pressure ( 26390057 29403010 27618448 30487518) Mean corpuscular hemoglobin ( 32888494) Myocardial infarction ( 26343387) Pulse pressure ( 29403010 28739976 30487518 30578418) Red cell distribution width ( 27863252) Response to citalopram or escitalopram and depression ( 27622933) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Reticulocyte fraction of red cells ( 27863252) Schizophrenia ( 28991256 25056061 21926974 29483656 22688191 30285260 23974872 23894747) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 26390057 28135244 19430483 21909115 29403010 28739976 27618447 27618452 30487518) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure (long-term average) ( 28348047) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) White matter lesion progression ( 26451028)
Interacting Genes		22 interacting genes: BHLHE40 DAZAP2 DNAJA3 DUSP29 EPM2AIP1 IKZF1 KRT15 KRTAP19-6 LINC00839 LNPK NECAB2 NT5C2 OXER1 PICK1 PLSCR1 PRSS23 TSC22D4 UBQLN2 USHBP1 VIM ZBTB42 ZNRD2	11 interacting genes: ATP5PO CALM1 FXR2 GLYCTK MOB1B MOB3B MOB3C NME7 NOC4L NUDT18 SDCBP
Entrez ID		79050	22978
HPRD ID		14543	02686
Ensembl ID		ENSG00000184967	ENSG00000076685
Uniprot IDs		Q9BVI4	A0A384MED8 A8K6K2 P49902
PDB IDs			2J2C 2JC9 2JCM 2XCV 2XCW 2XCX 2XJB 2XJC 2XJD 2XJE 2XJF 4H4B 5CQZ 5CR7 5K7Y 5L4Z 5L50 5OPK 5OPL 5OPM 5OPN 5OPO 5OPP 6DD3 6DDB 6DDC 6DDH 6DDK 6DDL 6DDO 6DDQ 6DDX 6DDY 6DDZ 6DE0 6DE1 6DE2 6DE3 6FIR 6FIS 6FIU 6FIW 6FXH
Enriched GO Terms of Interacting Partners?
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