RAB7A and H1-10

Data Source:
BioGRID (affinity chromatography technology)

		RAB7A	H1-10
Description		RAB7A, member RAS oncogene family	H1.10 linker histone
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GO Annotations	Cellular Component	Autophagosome Membrane Lysosome Lysosomal Membrane Late Endosome Lipid Droplet Cytosol Plasma Membrane Endosome Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Retromer Complex Late Endosome Membrane Extrinsic Component Of Lysosome Membrane Melanosome Membrane Phagocytic Vesicle Extracellular Exosome	Nucleosome Nucleus Nucleoplasm Nucleolus
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Retromer Complex Binding	Double-stranded DNA Binding RNA Binding Nucleosomal DNA Binding Cadherin Binding
	Biological Process	Autophagosome Assembly Protein Targeting To Lysosome Endocytosis Epidermal Growth Factor Catabolic Process Endosome To Lysosome Transport Protein Transport Lipid Catabolic Process Viral Release From Host Cell Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Protein To Membrane Docking Retrograde Transport, Endosome To Golgi Neutrophil Degranulation Early Endosome To Late Endosome Transport Positive Regulation Of Protein Catabolic Process Positive Regulation Of Viral Process Lipophagy Phagosome Maturation Phagosome Acidification Phagosome-lysosome Fusion Endosome To Plasma Membrane Protein Transport Multi-organism Intercellular Transport Negative Regulation Of Exosomal Secretion Positive Regulation Of Exosomal Secretion Negative Regulation Of Intralumenal Vesicle Formation	Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination
Pathways		MHC class II antigen presentation Neutrophil degranulation TBC/RABGAPs RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Suppression of autophagy
Drugs		Guanosine-5'-Diphosphate
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS		Body fat mass ( 28552196) Facial morphology traits (63 three-dimensional facial segments) ( 29459680)
Interacting Genes		27 interacting genes: CHM KRTAP10-3 KRTAP10-9 PPP2R1A PPP2R1B PRKN RAB13 RAB17 RAB22A RAB4A RAB4B RAB6A RABAC1 RABGGTB RILP RNF115 SLC2A4 SNX3 TP53 UCHL5 VPS11 VPS16 VPS18 VPS26A VPS29 VPS39 VPS41	3 interacting genes: CDC42 IL7R XBP1
Entrez ID		7879	8971
HPRD ID		03805	04151
Ensembl ID		ENSG00000075785	ENSG00000184897
Uniprot IDs		A0A158RFU6 P51149	Q92522
PDB IDs		1T91 1YHN 3LAW 6IYB 6WCW	2LSO
Enriched GO Terms of Interacting Partners?
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