ZIC2 and GLI2

Data Source:
HPRD (in vitro)

		ZIC2	GLI2
Description		Zic family member 2	GLI family zinc finger 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body	Nucleus Nucleoplasm Nucleolus Cytosol Cilium Axoneme Membrane Nuclear Speck Motile Cilium Ciliary Tip Ciliary Base
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin DNA Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Visual Perception Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development In Utero Embryonic Development Kidney Development Chondrocyte Differentiation Osteoblast Development Regulation Of Transcription By RNA Polymerase II Smoothened Signaling Pathway Pattern Specification Process Axon Guidance Ventral Midline Development Hindgut Morphogenesis Heart Development Anterior/posterior Pattern Specification Proximal/distal Pattern Formation Floor Plate Formation Spinal Cord Dorsal/ventral Patterning Ventral Spinal Cord Development Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Spinal Cord Ventral Commissure Morphogenesis Pituitary Gland Development Lung Development Mammary Gland Development Hindbrain Development Hair Follicle Morphogenesis Negative Regulation Of Chondrocyte Differentiation Positive Regulation Of T Cell Differentiation In Thymus Tube Development Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Digestive Tract Development Developmental Growth Neuron Development Branching Morphogenesis Of An Epithelial Tube Notochord Regression Prostatic Bud Formation Mammary Gland Duct Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cellular Response To Organic Cyclic Compound Cochlea Morphogenesis Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Pathways			Degradation of GLI2 by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription RUNX2 regulates chondrocyte maturation
Drugs
Diseases		Holoprosencephaly (HPE)	Holoprosencephaly (HPE)
GWAS		Hyperopia ( 25233373) Myopia ( 27182965) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Acne (severe) ( 30542056) Age-related macular degeneration ( 23326517) Breast size ( 22747683) Diastolic blood pressure ( 30224653) Diisocyanate-induced asthma ( 25918132) Erectile dysfunction and prostate cancer treatment ( 20932654) Estimated glomerular filtration rate ( 31015462) Estimated glomerular filtration rate in coronary artery disease and impaired kidney function ( 30809046) Glomerular filtration rate (creatinine) ( 26831199) Height ( 28552196 25429064 31562340) Serum uric acid levels ( 30993211) Type 2 diabetes ( 30054458 30297969)
Interacting Genes		3 interacting genes: GLI1 GLI2 GLI3	12 interacting genes: AR BTRC CREB1 FBXW11 OTUB2 SKI SPOP STK36 SUFU TAF9 ZIC1 ZIC2
Entrez ID		7546	2736
HPRD ID		04353	01312
Ensembl ID		ENSG00000043355	ENSG00000074047
Uniprot IDs		A0A024RDY6 O95409	P10070 Q1PSW9 Q59FV5
PDB IDs
Enriched GO Terms of Interacting Partners?
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