YY1 and MTA2

Data Source:
BioGRID (pull down)

		YY1	MTA2
Description		YY1 transcription factor	metastasis associated 1 family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Chromatin Silencing Complex Cytoplasm Nuclear Matrix Ino80 Complex PcG Protein Complex	Histone Deacetylase Complex Chromatin Nucleoplasm Transcription Regulator Complex Membrane NuRD Complex Protein-containing Complex
	Molecular Function	Four-way Junction DNA Binding Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding RNA Binding Protein Binding SMAD Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Regulation Of Transcription By RNA Polymerase II RNA Localization Cellular Response To DNA Damage Stimulus Spermatogenesis Anterior/posterior Pattern Specification Response To UV-C Negative Regulation Of Gene Expression Protein Deubiquitination B Cell Differentiation Negative Regulation Of Interferon-beta Production Cellular Response To UV Response To Prostaglandin F Positive Regulation Of Transcription By RNA Polymerase II Cell Development Camera-type Eye Morphogenesis Chromosome Organization Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Interleukin-1 Immunoglobulin Heavy Chain V-D-J Recombination Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Assembly Or Disassembly Regulation Of Fibroblast Migration Histone Deacetylation ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis UCH proteinases DNA Damage Recognition in GG-NER TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Estrogen-dependent gene expression	HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Pulse pressure ( 30224653)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		90 interacting genes: ALOXE3 APP ATF2 ATF6 ATF7 AURKA BAP1 BCCIP BRCA1 CDKN2A CEP76 CREB1 CRKL CYSRT1 DNMT3L E2F2 E2F3 EED EP300 ESM1 FHL2 FKBP1A FKBP3 GMCL1 GRN GTF2I HCFC1 HDAC2 HDAC3 HOXA11 IL10 INO80 KAT2B KRTAP1-3 KRTAP1-5 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP4-2 KRTAP4-5 KRTAP5-6 KRTAP9-3 KRTAP9-8 LHX3 LHX4 MDFI MED20 MTA2 MYC NEDD4L NFKB1 NOTCH1 NPM1 NR1H2 PLEKHF2 PPIA PSMD9 RAF1 RUVBL1 RUVBL2 RYBP SAP30 SF3A2 SKP2 SLC39A7 SMAD1 SMAD2 SMAD3 SMURF2 SP1 SPRY1 SREBF1 TESK1 TFCP2 TP53 TRIM42 TWIST1 UHRF2 VWC2 XAGE1A XAGE1B YAF2 ZNF232 ZNF85 ZRANB2	23 interacting genes: APPL1 APPL2 BCL11B ERCC6 ESR1 FKBP3 H3-4 HNRNPD MBD3 MBD3L2 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C USP11 YY1
Entrez ID		7528	9219
HPRD ID		02482	07233
Ensembl ID		ENSG00000100811	ENSG00000149480
Uniprot IDs		P25490	A0A024R534 O94776
PDB IDs		1UBD 1ZNM 4C5I
Enriched GO Terms of Interacting Partners?
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