NSD2 and HORMAD2

Data Source:
BioGRID (two hybrid)

		NSD2	HORMAD2
Description		nuclear receptor binding SET domain protein 2	HORMA domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm	Synaptonemal Complex Nucleus Nucleoplasm Chromosome Centrosome Cytosol
	Molecular Function	Chromatin Binding Protein Binding Histone Methyltransferase Activity (H4-K20 Specific) Sequence-specific DNA Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Membranous Septum Morphogenesis Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone H4-K20 Methylation Positive Regulation Of Isotype Switching To IgA Isotypes Bone Development Regulation Of Establishment Of Protein Localization Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Meiotic Sister Chromatid Cohesion Meiotic Cell Cycle
Pathways		PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases		Multiple myeloma
GWAS		Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)	Albumin-globulin ratio ( 29403010) Autoimmune thyroid disease ( 32581359) Creatine kinase levels ( 29403010) Crohn's disease ( 28067908) Delirium ( 29631748) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) IgA nephropathy ( 26028593 25305756) Inflammatory bowel disease ( 28067908) Inflammatory bowel disease (early onset) ( 19915574) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Moyamoya disease ( 29273593) Nephropathy ( 21399633) Neutrophil percentage of white cells ( 32888494 27863252) Non-albumin protein levels ( 29403010) Optic cup area ( 31798171) Optic disc area ( 25631615) Tonsillectomy ( 27941131) Type 1 diabetes ( 30572963) Type 2 diabetes ( 30054458) Vertical cup-disc ratio ( 31798171) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		12 interacting genes: AGO2 APP AR AURKA ESR1 H3-4 H3C1 H3C14 HORMAD2 MDC1 PCNA PLEKHF2	2 interacting genes: NSD2 SYCP2
Entrez ID		7468	150280
HPRD ID		04259	13668
Ensembl ID		ENSG00000109685	ENSG00000176635
Uniprot IDs		O96028	Q8N7B1
PDB IDs		5LSU 5VC8 6UE6 6XCG 7CRO
Enriched GO Terms of Interacting Partners?
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