WEE1 and BRSK2

Data Source:
HPRD (in vitro)

		WEE1	BRSK2
Description		WEE1 G2 checkpoint kinase	BR serine/threonine kinase 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm	Nucleus Cytoplasm Endoplasmic Reticulum Centrosome Perinuclear Region Of Cytoplasm Distal Axon
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity	Magnesium Ion Binding Protein Serine/threonine Kinase Activity ATP Binding Protein Kinase Binding Tau Protein Binding Tau-protein Kinase Activity ATPase Binding ATPase Regulator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Microtubule Cytoskeleton Organization Mitotic Cell Cycle Checkpoint Peptidyl-tyrosine Phosphorylation Establishment Of Cell Polarity Neuron Projection Morphogenesis Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	G2/M Transition Of Mitotic Cell Cycle Protein Phosphorylation Exocytosis Axonogenesis Regulation Of Neuron Projection Development Peptidyl-serine Phosphorylation Establishment Of Cell Polarity Neuron Differentiation Actin Cytoskeleton Reorganization Intracellular Signal Transduction ERAD Pathway Cellular Response To Glucose Starvation Regulation Of ATPase Activity Regulation Of Axonogenesis Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Microtubule Cytoskeleton Organization Involved In Establishment Of Planar Polarity Regulation Of Retrograde Protein Transport, ER To Cytosol Regulation Of Synaptic Vesicle Clustering
Pathways		Polo-like kinase mediated events Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Cyclin A:Cdk2-associated events at S phase entry Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Factors involved in megakaryocyte development and platelet production
Drugs		9-HYDROXY-4-PHENYL-6H-PYRROLO[3,4-C]CARBAZOLE-1,3-DIONE 9-HYDROXY-6-(3-HYDROXYPROPYL)-4-(2-METHOXYPHENYL)PYRROLO[3,4-C]CARBAZOLE-1,3(2H,6H)-DIONE N-[4-(2-CHLOROPHENYL)-1,3-DIOXO-1,2,3,6-TETRAHYDROPYRROLO[3,4-C]CARBAZOL-9-YL]FORMAMIDE 4-(2-chlorophenyl)-8-(2-hydroxyethyl)-6-methylpyrrolo[3,4-e]indole-1,3(2H,6H)-dione 3-(9-HYDROXY-1,3-DIOXO-4-PHENYL-2,3-DIHYDROPYRROLO[3,4-C]CARBAZOL-6(1H)-YL)PROPANOIC ACID 8-bromo-4-(2-chlorophenyl)-N-(2-hydroxyethyl)-6-methyl-1,3-dioxo-1,2,3,6-tetrahydropyrrolo[3,4-e]indole-7-carboxamide MK-1775 Fostamatinib
Diseases
GWAS		Cutaneous squamous cell carcinoma ( 32041948) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Platelet distribution width ( 32888494)	Brain morphology (MOSTest) ( 32665545) Gout ( 32238385) Heroin dependence ( 27936112) Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		22 interacting genes: BRD8 BRSK1 BRSK2 BTRC CASP3 CDCA3 CDK1 CDK2 CRK CSNK2A1 ERRFI1 FBXW11 NEDD4 PIN1 PLK1 SKP2 SMAD3 SMURF1 YWHAB YWHAG YWHAQ YWHAZ	7 interacting genes: CDC25B CDC25C COPS5 MAPT TRAF6 VCP WEE1
Entrez ID		7465	9024
HPRD ID		01907	11611
Ensembl ID		ENSG00000166483	ENSG00000174672
Uniprot IDs		P30291 Q86V29	A0A024RCE9 A0A140VJF6 B4DLY3 Q8IWQ3
PDB IDs		1X8B 2IN6 2IO6 2Z2W 3BI6 3BIZ 3CQE 3CR0 5V5Y 5VC3 5VC4 5VC5 5VC6 5VD2 5VD4 5VD5 5VD7 5VD8 5VD9 5VDA
Enriched GO Terms of Interacting Partners?
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