KDM6A and BMP15

Data Source:
BioGRID (two hybrid)

		KDM6A	BMP15
Description		lysine demethylase 6A	bone morphogenetic protein 15
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Extracellular Space Endoplasmic Reticulum Lumen
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Chromatin DNA Binding Metal Ion Binding Dioxygenase Activity Histone Demethylase Activity (H3-K27 Specific)	Cytokine Activity Growth Factor Activity Type I Activin Receptor Binding
	Biological Process	Chromatin Remodeling Heart Development Regulation Of Gene Expression Histone H3-K4 Methylation Histone H3-K27 Demethylation	Ovarian Follicle Development Female Gamete Generation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation BMP Signaling Pathway Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Granulosa Cell Development SMAD Protein Signal Transduction
Pathways		HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases			Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS
Interacting Genes		11 interacting genes: GSC2 H3-4 H3C1 H3C14 MEOX2 MTDH NKX2-5 SMAD9 SRF TBX5 TLE1	2 interacting genes: BMPR1B GDF9
Entrez ID		7403	9210
HPRD ID		02131	02216
Ensembl ID		ENSG00000147050	ENSG00000130385
Uniprot IDs		A0A087X0R0 A0A6Q8PFK0 B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3 Q86TD1	O95972
PDB IDs		3AVR 3AVS 6FUK 6FUL
Enriched GO Terms of Interacting Partners?
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