KDM6A and GSC2

Data Source:
BioGRID (two hybrid)

		KDM6A	GSC2
Description		lysine demethylase 6A	goosecoid homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Chromatin DNA Binding Metal Ion Binding Dioxygenase Activity Histone Demethylase Activity (H3-K27 Specific)	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Remodeling Heart Development Regulation Of Gene Expression Histone H3-K4 Methylation Histone H3-K27 Demethylation	Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis
Pathways		HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS			Metabolite levels ( 22916037)
Interacting Genes		11 interacting genes: GSC2 H3-4 H3C1 H3C14 MEOX2 MTDH NKX2-5 SMAD9 SRF TBX5 TLE1	60 interacting genes: ALPP ANXA5 ASPH BEST3 BNIP2 C19orf47 C1D CALM1 CALM2 CALM3 CALR CDKN2D CIAO2A COL8A1 CRCP CSNK2A1 DYRK1B EGLN3 EIF5A ETFDH FAM221B FKBP6 GALNT11 GCM2 GTF2H5 GTSF1L GUCA1A GUCY1A2 HMBOX1 ISX KDM6A KLHL38 KRT34 KRTAP5-9 LCE3E LTO1 MAD2L2 MAPK9 MARF1 MID2 MORF4L1 MRPL53 MRPS23 NME7 PACSIN2 PDE4C PRKAB2 PTER RNF4 SCAF1 SDCBP TIPIN TNPO2 TSR2 UBE2R2 VCX2 XRCC4 YPEL5 ZNF444 ZNF587
Entrez ID		7403	2928
HPRD ID		02131	03506
Ensembl ID		ENSG00000147050	ENSG00000063515
Uniprot IDs		A0A087X0R0 A0A6Q8PFK0 B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3 Q86TD1	O15499
PDB IDs		3AVR 3AVS 6FUK 6FUL
Enriched GO Terms of Interacting Partners?
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