UPP1 and CTDP1

Data Source:
BioGRID (enzymatic study)

		UPP1	CTDP1
Description		uridine phosphorylase 1	CTD phosphatase subunit 1
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GO Annotations	Cellular Component	Nucleoplasm Cytosol	Spindle Pole Nucleus Nucleoplasm Cytoplasm Centrosome Spindle Midbody Protein-containing Complex Intracellular Membrane-bounded Organelle Spindle Midzone
	Molecular Function	Uridine Phosphorylase Activity Thymidine Phosphorylase Activity Identical Protein Binding	TFIIF-class Transcription Factor Complex Binding Phosphoprotein Phosphatase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Tat Protein Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Nucleobase-containing Compound Metabolic Process Uridine Catabolic Process Cellular Response To Glucose Starvation Pyrimidine Nucleoside Salvage UMP Salvage UMP Catabolic Process DTMP Catabolic Process Pyrimidine Nucleoside Catabolic Process	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Protein Dephosphorylation Exit From Mitosis Positive Regulation By Host Of Viral Transcription Positive Regulation Of Viral Transcription Cell Division Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Dephosphorylation Of RNA Polymerase II C-terminal Domain
Pathways		Pyrimidine salvage Pyrimidine catabolism	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs		5-Benzylacyclouridine
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483)	Adverse response to drug ( 30420678) Cerebrospinal P-tau181p levels ( 28247064) Metabolite levels ( 23823483) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494) Schizophrenia ( 23212062) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		2 interacting genes: CTDP1 VIM	40 interacting genes: CDK7 CDK8 CDK9 CSNK2A1 CSNK2A2 CSNK2B E2F1 ELP2 ELP3 ERH GTF2F1 INTS1 INTS3 INTS6 INTS7 INTS8 MED1 MED14 MED15 MED16 MED17 MED23 MED24 MED25 MED26 MED4 MED6 MED7 MED8 NDRG2 POLR2A POLR2B PRKDC PRMT5 SNRNP70 SNRPB STK38 TCEA1 UPP1 WDR77
Entrez ID		7378	9150
HPRD ID		08932	05377
Ensembl ID		ENSG00000183696	ENSG00000060069
Uniprot IDs		B4DND0 Q16831 Q86Y75	A0A0A0MR03 Q9Y5B0
PDB IDs		3EUE 3EUF 3NBQ	1J2X 1ONV 2K7L
Enriched GO Terms of Interacting Partners?
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