UCHL3 and ATXN7L3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		UCHL3	ATXN7L3
Description		ubiquitin C-terminal hydrolase L3	ataxin 7 like 3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	SAGA Complex Nucleus DUBm Complex
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity NEDD8-specific Protease Activity Ubiquitin Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Receptor Coactivator Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Protein Catabolic Process Post-translational Protein Modification	Regulation Of Transcription By RNA Polymerase II Histone Monoubiquitination Histone Deubiquitination Positive Regulation Of Transcription, DNA-templated
Pathways		UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation	HATs acetylate histones
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483)	Bipolar disorder ( 31043756) Height ( 31562340)
Interacting Genes		20 interacting genes: ATM ATXN7L3 CDH1 FOXM1 LONRF1 NEDD8 NSG2 PJA1 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBE2S USP15 USP21 USP28 XRCC5	11 interacting genes: APP ENY2 H2AC20 H2BC21 PICK1 SECISBP2 SERTAD1 UBC UCHL3 USP22 USP6
Entrez ID		7347	56970
HPRD ID		04367	12507
Ensembl ID		ENSG00000118939	ENSG00000087152
Uniprot IDs		A0A087WTB8 A0A140VJZ4 P15374	Q14CW9
PDB IDs		1UCH 1XD3 6ISU 6QML	2KKT
Enriched GO Terms of Interacting Partners?
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