UBA1 and UBE2B

Data Source:
BioGRID (enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down)

		UBA1	UBE2B
Description		ubiquitin like modifier activating enzyme 1	ubiquitin conjugating enzyme E2 B
Image
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Lysosomal Membrane Cytosol Endosome Membrane Desmosome Rough Endoplasmic Reticulum Membrane Extracellular Exosome	Chromatin XY Body Nucleus Nucleoplasm Replication Fork Cytoplasm Plasma Membrane HULC Complex
	Molecular Function	RNA Binding Ubiquitin Activating Enzyme Activity Protein Binding ATP Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Protein Ubiquitination Protein Phosphopantetheinylation Protein Modification By Small Protein Conjugation	Protein Polyubiquitination In Utero Embryonic Development DNA Repair Postreplication Repair Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Spermatogenesis Sperm Axoneme Assembly Response To UV Positive Regulation Of Reciprocal Meiotic Recombination Protein Ubiquitination Histone Ubiquitination Negative Regulation Of Histone Phosphorylation Histone H2A Ubiquitination Response To Drug DNA Damage Response, Detection Of DNA Damage Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of CAMP-mediated Signaling Meiotic Telomere Clustering Protein Stabilization Chiasma Assembly Protein Autoubiquitination Histone Lysine Demethylation Synaptonemal Complex Organization Protein K63-linked Ubiquitination Heterochromatin Maintenance Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Recognition of DNA damage by PCNA-containing replication complex Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Hexatantalum Dodecabromide Quercetin
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS			Relative amplitude of rest-activity cycles ( 30120083)
Interacting Genes		51 interacting genes: ABCF1 BUB3 CDC34 CDK1 CHEK1 ECHS1 GAN GRB2 HGS HSPH1 LINC01554 MGMT MTNR1A PIAS3 SEMA3F SMAD5 SUMO2 TAF9 TMCC2 TSSC4 TTC19 UBC UBE2A UBE2B UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G1 UBE2G2 UBE2H UBE2J1 UBE2J2 UBE2K UBE2L1 UBE2L3 UBE2L6 UBE2M UBE2N UBE2Q2 UBE2R2 UBE2S UBE2T UBE2U UBE2W UBE2Z UBTD2	25 interacting genes: BIRC2 CBX5 CDKN1B CNOT4 CRMP1 CTNNB1 H2AC20 HERPUD2 MED31 PCNA PRKN RAD18 RC3H1 RC3H2 RNF20 RNF4 RNF40 TRIM14 TRIM45 UBA1 UBR1 UBR2 UBR3 UBR5 UNC119
Entrez ID		7317	7320
HPRD ID		02440	01533
Ensembl ID		ENSG00000130985	ENSG00000119048
Uniprot IDs		A0A024R1A3 P22314	P63146
PDB IDs		4P22 6DC6	1JAS 1NXA 2Y4W 2YB6 2YBF
Enriched GO Terms of Interacting Partners?
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