TTC3 and POLG

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		TTC3	POLG
Description		tetratricopeptide repeat domain 3	DNA polymerase gamma, catalytic subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Golgi Apparatus Cytosol	Mitochondrion Gamma DNA Polymerase Complex Protein-containing Complex Mitochondrial Nucleoid Terminal Bouton
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding	Protease Binding DNA Binding Chromatin Binding DNA-directed DNA Polymerase Activity Protein Binding 3'-5' Exonuclease Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination	DNA Metabolic Process DNA-dependent DNA Replication Mitochondrial DNA Replication Base-excision Repair, Gap-filling Aging Response To Light Stimulus Response To Gamma Radiation Response To Hyperoxia Cellular Response To Glucose Stimulus DNA Biosynthetic Process Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases			Mitochondrial DNA depletion syndrome (MDS)
GWAS		Eye color traits ( 20463881)	Height ( 18193045) Menopause (age at onset) ( 22267201 26414677) Schizophrenia ( 28991256) Smoking status (ever vs never smokers) ( 30643258) Venlafaxine response in generalised anxiety disorder (responders vs non-responders after 24 weeks) ( 28437668)
Interacting Genes		9 interacting genes: AKT1 ATF7IP HSPB1 MIR7-1 POLG TTN UBE2D2 UBE2E3 UBE3A	2 interacting genes: SSBP1 TTC3
Entrez ID		7267	5428
HPRD ID		03773	01438
Ensembl ID		ENSG00000182670	ENSG00000140521
Uniprot IDs		P53804	E5KNU5 P54098
PDB IDs			3IKM 4ZTU 4ZTZ 5C51 5C52 5C53
Enriched GO Terms of Interacting Partners?
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