HSP90B1 and MTTP

Data Source:
HPRD (in vivo)

		HSP90B1	MTTP
Description		heat shock protein 90 beta family member 1	microsomal triglyceride transfer protein
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Focal Adhesion Membrane Midbody Protein-containing Complex Sarcoplasmic Reticulum Lumen Melanosome Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Rough Endoplasmic Reticulum Golgi Apparatus Basolateral Plasma Membrane Brush Border Membrane Microvillus Membrane Vesicle Receptor Complex
	Molecular Function	RNA Binding Calcium Ion Binding Protein Binding ATP Binding Protein Phosphatase Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding	Lipid Transporter Activity Protein Binding Phospholipid Transporter Activity Lipid Binding Apolipoprotein Binding Protein-containing Complex Binding Protein Heterodimerization Activity Phospholipid Transfer Activity Phosphatidylcholine Transfer Activity Cholesterol Transfer Activity Triglyceride Transfer Activity Ceramide 1-phosphate Transfer Activity Phosphatidylethanolamine Transfer Activity
	Biological Process	Response To Hypoxia Toll-like Receptor Signaling Pathway Protein Folding Receptor-mediated Endocytosis Protein Transport Cytokine-mediated Signaling Pathway Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Actin Rod Assembly Protein Folding In Endoplasmic Reticulum Response To Endoplasmic Reticulum Stress ATF6-mediated Unfolded Protein Response Negative Regulation Of Apoptotic Process Regulation Of Phosphoprotein Phosphatase Activity Post-translational Protein Modification Cellular Protein Metabolic Process Sequestering Of Calcium Ion Cellular Response To ATP	Protein Lipidation Lipid Metabolic Process Triglyceride Metabolic Process Circadian Rhythm Protein Secretion Phospholipid Transport Sterol Transport Triglyceride Transport Low-density Lipoprotein Particle Remodeling Plasma Lipoprotein Particle Assembly Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Lipoprotein Metabolic Process Cholesterol Homeostasis Lipoprotein Transport Response To Calcium Ion Intermembrane Lipid Transfer Ceramide 1-phosphate Transport
Pathways		Trafficking and processing of endosomal TLR Scavenging by Class A Receptors Scavenging by Class A Receptors ATF6 (ATF6-alpha) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling Post-translational protein phosphorylation	VLDL assembly Chylomicron assembly
Drugs		Rifabutin 2-Chlorodideoxyadenosine Geldanamycin Diglyme N-Ethyl-5'-Carboxamido Adenosine Radicicol METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE Copper	Hesperetin Implitapide SLx-4090 Lomitapide
Diseases			Abetalipoproteinemia; Bassen-Kornzweig Disease
GWAS		Blood protein levels ( 29875488) Metabolite levels ( 23823483) Soluble VCAM-1 levels ( 31217265)	Celiac disease ( 23936387) HDL cholesterol ( 30275531) Regular attendance at a pub or social club ( 29970889) Triglyceride levels ( 32203549)
Interacting Genes		36 interacting genes: APOB ASGR1 BIRC2 CACYBP CAMLG CCT2 CSNK2A1 CSNK2A2 CYSLTR2 EGFR ERBB2 ESR1 FANCC GPR37 HSPA9 LINC01554 LRP1 MAPK6 MDM2 MTTP NKX3-1 OS9 POLR2E PTEN PTPN11 RXFP3 SGTB SIRPA SUPT6H TG TLR1 TLR2 TLR4 TP53 TXNDC11 UBASH3A	2 interacting genes: APOB HSP90B1
Entrez ID		7184	4547
HPRD ID		01860	01144
Ensembl ID		ENSG00000166598	ENSG00000138823
Uniprot IDs		P14625 V9HWP2	B7Z7X3 E9PBP6 P55157
PDB IDs		4NH9
Enriched GO Terms of Interacting Partners?
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