TNP2 and PRKACB

Data Source:
BioGRID (enzymatic study)

		TNP2	PRKACB
Description		transition protein 2	protein kinase cAMP-activated catalytic subunit beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus	Nucleus Nucleoplasm Centrosome Cytosol Plasma Membrane CAMP-dependent Protein Kinase Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Ciliary Base
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding	Magnesium Ion Binding AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding
	Biological Process	Multicellular Organism Development Spermatogenesis Acrosome Reaction Penetration Of Zona Pellucida Positive Regulation Of Protein Processing Spermatogenesis, Exchange Of Chromosomal Proteins	Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Renal Water Homeostasis Protein Phosphorylation Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Blood Coagulation Protein Kinase A Signaling Activation Of Protein Kinase A Activity High-density Lipoprotein Particle Assembly Negative Regulation Of Meiotic Cell Cycle Regulation Of Protein Processing Cellular Response To Glucagon Stimulus Response To Clozapine Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning
Pathways			PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling HDL assembly ROBO receptors bind AKAP5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			Phosphonothreonine Fostamatinib
Diseases
GWAS		Asthma ( 31959851) Bulimia nervosa ( 23568457) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 22190364) Type 1 diabetes ( 18978792)	Breast cancer (male) ( 23001122) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: APPBP2 KRTAP1-1 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP2-3 KRTAP2-4 MDFI NOTCH2NLA PRKACA PRKACB PRKACG PRKCA	15 interacting genes: ACVR1B APPBP2 ARFGAP1 AVPI1 CSNK2A1 FBXO7 NGFR PKIA PKIB RPL27A RPS6 SPP1 TNP1 TNP2 TP73
Entrez ID		7142	5567
HPRD ID		01831	01482
Ensembl ID		ENSG00000178279	ENSG00000142875
Uniprot IDs		Q05952 Q4VB56	A0A087WVC4 B1APF9 B1APG3 B2RB89 B7ZA00 P22694
PDB IDs
Enriched GO Terms of Interacting Partners?
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