TLN1 and DAG1

Data Source:
BioGRID (fluorescent resonance energy transfer)

		TLN1	DAG1
Description		talin 1	dystroglycan 1
Image
GO Annotations	Cellular Component	Ruffle Extracellular Region Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Ruffle Membrane Extracellular Exosome	Extracellular Region Basement Membrane Extracellular Space Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion External Side Of Plasma Membrane Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Integral Component Of Membrane Lamellipodium Filopodium Node Of Ranvier Nuclear Periphery Sarcolemma Costamere Intracellular Membrane-bounded Organelle Plasma Membrane Raft Postsynaptic Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Contractile Ring Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Cytosol
	Molecular Function	Phosphatidylserine Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Phosphatidylinositol Binding Cadherin Binding Actin Filament Binding	Virus Receptor Activity Dystroglycan Binding Actin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Tubulin Binding Vinculin Binding SH2 Domain Binding Laminin Binding Laminin-1 Binding Alpha-actinin Binding
	Biological Process	Platelet Degranulation Muscle Contraction Cell-cell Junction Assembly Cell-substrate Junction Assembly Integrin-mediated Signaling Pathway Viral Process Cortical Actin Cytoskeleton Organization Integrin Activation IRE1-mediated Unfolded Protein Response Platelet Aggregation Cell-cell Adhesion	Positive Regulation Of Cell-matrix Adhesion Morphogenesis Of An Epithelium Morphogenesis Of An Epithelial Sheet Membrane Protein Ectodomain Proteolysis Axon Guidance Aging Regulation Of Gastrulation Regulation Of Epithelial To Mesenchymal Transition Response To Denervation Involved In Regulation Of Muscle Adaptation Muscle Attachment Calcium-dependent Cell-matrix Adhesion Regulation Of Embryonic Cell Shape Modulation By Virus Of Host Process Nerve Development Nerve Maturation Myelination In Peripheral Nervous System Extracellular Matrix Organization Negative Regulation Of Cell Migration Axon Regeneration Positive Regulation Of Myelination Microtubule Anchoring Skeletal Muscle Tissue Regeneration Negative Regulation Of MAPK Cascade Response To Peptide Hormone Positive Regulation Of Protein Kinase Activity Viral Entry Into Host Cell Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Synapse Organization Negative Regulation Of Protein Kinase B Signaling Angiogenesis Involved In Wound Healing Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Cellular Response To Mechanical Stimulus Cellular Response To Cholesterol Commissural Neuron Axon Guidance Basement Membrane Organization Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways		Platelet degranulation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins XBP1(S) activates chaperone genes SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Smooth Muscle Contraction MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 O-linked glycosylation Regulation of expression of SLITs and ROBOs EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases			Limb-girdle muscular dystrophy (LGMD)
GWAS		Brain morphology (MOSTest) ( 32665545) IgE levels in asthmatics ( 23967269) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494)	Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Pediatric autoimmune diseases ( 26301688) Plateletcrit ( 32888494) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889) Resting heart rate ( 27798624) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		29 interacting genes: ABI1 ACTA1 AZIN2 CDK5 DAG1 DOK1 EGFR ERBB2 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 MTNR1A MTNR1B NRAP PKD1 PTK2 PTK2B PXN SMURF1 SUMO2 TES TUBA1A VCL YWHAQ	25 interacting genes: AGR2 AGR3 AGRN BGN CAV1 CAV3 DMD DRP2 FYN GRB2 ITGB1 LAMA1 LAMA2 LAMA5 MAGI1 MAP2 NCK1 RAPSN SHC1 SRC TLN1 TUBA1A UTRN WWP1 WWP2
Entrez ID		7094	1605
HPRD ID		01726	00546
Ensembl ID		ENSG00000137076	ENSG00000173402
Uniprot IDs		Q9Y490	A0A024R2W4 Q14118
PDB IDs		1SYQ 2MWN 4DJ9 6R9T	1EG4 2MK7 5GGP 5LLK 6JJY
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?