TLE2 and UTY

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		TLE2	UTY
Description		TLE family member 2, transcriptional corepressor	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Transcription Regulator Complex Focal Adhesion Nuclear Body	Nucleoplasm MLL3/4 Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Chromatin DNA Binding Metal Ion Binding Dioxygenase Activity Histone Demethylase Activity (H3-K27 Specific)
	Biological Process	Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly	Heart Development Regulation Of Gene Expression Histone H3-K27 Demethylation
Pathways		Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes	HDMs demethylate histones
Drugs
Diseases
GWAS			Autism ( 32996047)
Interacting Genes		16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX	3 interacting genes: PRDX2 TLE1 TLE2
Entrez ID		7089	7404
HPRD ID		03025	02451
Ensembl ID		ENSG00000065717	ENSG00000183878
Uniprot IDs		K7EMK7 Q04725	A0A087X0Y2 A0A087X248 A0A087X2I9 A0A096LPD8 E1NZ93 E1U198 E1U1M3 E1U1M9 F4MH27 F4MH29 F4MH30 F4MH31 F4MH32 F4MH35 F4MH36 F4MH40 F4MH46 F4MH47 F4MH50 F4MH51 F4MH58 F4MH60 F4MH62 F4MH91 F4MH92 F5GWV3 F5H3N7 F5H8B4 O14607
PDB IDs			3ZLI 3ZPO 4UF0 5A1L 5FXV 5FXW 5FXX 5FXZ 5FY0 5FY1 5FY7 5FYM
Enriched GO Terms of Interacting Partners?
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