C1QBP and TOP3B

Data Source:
HPRD (two hybrid)

		C1QBP	TOP3B
Description		complement C1q binding protein	DNA topoisomerase III beta
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Cell Surface Membrane Presynaptic Active Zone Glutamatergic Synapse GABA-ergic Synapse	Condensed Chromosome Nucleus
	Molecular Function	Complement Component C1q Complex Binding Transcription Corepressor Activity MRNA Binding Protein Kinase C Binding Protein Binding Hyaluronic Acid Binding Transcription Factor Binding Translation Activator Activity Kininogen Binding Adrenergic Receptor Binding Mitochondrial Ribosome Binding	DNA Binding RNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Processing Apoptotic Process Immune Response Complement Activation, Classical Pathway Blood Coagulation, Intrinsic Pathway RNA Splicing Phosphatidylinositol 3-kinase Signaling Viral Process Regulation Of Complement Activation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Mature Ribosome Assembly Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Adhesion Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Defense Response To Virus Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Translation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Trophoblast Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis	DNA Topological Change Chromosome Segregation
Pathways		Apoptotic factor-mediated response Intrinsic Pathway of Fibrin Clot Formation Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
Drugs		Hyaluronic acid Copper
Diseases
GWAS		Rheumatoid arthritis ( 30423114 24390342)	Attention function in attention deficit hyperactive disorder ( 26174813) Bipolar disorder ( 31043756) Diastolic blood pressure ( 29208002) Response to selective serotonin reuptake inhibitors in depression ( 27622933)
Interacting Genes		99 interacting genes: C1QA CEBPA COIL DUX4 EXOSC6 GAB1 GABRB1 HABP4 HMGB1 HMGB2 HNRNPD HRK KLF1 MAPK1 MAPK3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MMP14 NFKBIE NFYB PRKCA PRKCD PRKCZ PRKD1 PRRC2A SRSF1 SRSF9 TOP3B YWHAB YWHAG	24 interacting genes: ADAMTSL4 AXIN2 BHLHB9 C1QBP CENPF CHD8 CHIC2 CIAO1 FASTK FBLN5 GRN KANK2 KRTAP4-12 MID2 PNMA2 RECQL5 SNRPB SPRED2 SSX2IP TRIM41 UPF2 ZFPM1 ZNF250 ZNF408
Entrez ID		708	8940
HPRD ID		03168	04662
Ensembl ID		ENSG00000108561	ENSG00000100038
Uniprot IDs		Q07021	A0A024R1C2 A8K4N2 O95985
PDB IDs		1P32 3RPX 6SZW	5GVC 5GVE
Enriched GO Terms of Interacting Partners?
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