TIMP2 and UBQLN2

Data Source:
BioGRID (two hybrid)

		TIMP2	UBQLN2
Description		TIMP metallopeptidase inhibitor 2	ubiquilin 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Surface Growth Cone Extracellular Matrix Specific Granule Lumen Neuronal Cell Body Collagen-containing Extracellular Matrix Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Autophagosome Cytosol Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	Protease Binding Integrin Binding Protein Binding Metalloendopeptidase Inhibitor Activity Zinc Ion Binding Peptidase Inhibitor Activity	Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding
	Biological Process	Central Nervous System Development Aging Negative Regulation Of Cell Population Proliferation Response To Hormone Response To Organic Substance Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Regulation Of Rap Protein Signal Transduction Response To Cytokine Response To Drug Neutrophil Degranulation Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Adenylate Cyclase Activity Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Metallopeptidase Activity	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Regulation Of Macroautophagy Ubiquitin-dependent ERAD Pathway Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Autophagosome Assembly
Pathways		Activation of Matrix Metalloproteinases Neutrophil degranulation	Cargo recognition for clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Dupuytren's disease ( 21732829) Heel bone mineral density ( 30598549) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Periodontitis (CDC/AAP) ( 24024966)
Interacting Genes		6 interacting genes: ITGA3 ITGB1 MMP14 MMP2 MMP8 UBQLN2	262 interacting genes: ABI2 ACOT7 ADAMTS3 ADRM1 AGR2 AGR3 AMBN ANKRD33 APOC2 APOC4 ARRDC3 ASCL1 ATXN7 AZGP1 BAG6 BCL2L11 BPIFA1 BTRC C1orf94 C1QA C1QB C1QC C1QL4 C1QTNF2 C1QTNF4 C6orf15 C8G CAPN15 CCDC158 CCK CCL16 CCL3 CCL7 CCN1 CD93 CD99L2 CDH15 CDH17 CDIP1 CDSN CEACAM6 CLEC11A CLPSL2 CNNM3 COL10A1 COL17A1 COL1A2 COL8A1 COL9A2 COLGALT2 CSN1S1 CSN2 CSN3 CST1 CST4 CSTF2 CSTF2T CTAG1A CTAG1B CTDNEP1 DAZAP2 DDR1 DEFA1 DEFA1B DEFA6 DEFB115 DESI1 DMKN DUSP21 ECM1 ECRG4 EFEMP1 EGFL6 ERP27 ERP29 ETNK1 F10 FAM168A FAM222B FBXO25 FDCSP FGF17 FKBP2 FNDC11 FUCA1 FUS FZD7 GAL GALP GHRL GPR162 GPX7 GUCA2A GUCA2B HEMK1 HERC3 HERPUD1 HGS HNRNPA3 HSD17B12 HSPA13 ICAM1 IFNA13 IGFBP6 IGLL1 IL11 IQCF3 IST1 ITPKB ITPRIPL1 JPH4 KISS1 KLHL11 KLHL42 KRT6A KRTAP12-1 KRTAP13-1 KRTAP19-3 KRTAP19-5 LAIR2 LASP1 LATS1 LCN1 LCN2 LITAF LMO4 LY6G6D MAGED1 MBL2 MDK MICOS10-NBL1 MIEF1 MIEF2 MINPP1 MOAP1 MTNR1B MTX2 MYDGF MYO15B NAXD NBL1 NDOR1 NME3 NOC4L NOL3 NPBWR1 NPPA NPVF NPY NRN1L NT5C3A NUP58 ODAPH OPN4 OR7D4 OSMR PARM1 PCDHGA9 PIANP PIK3IP1 PIN1 PLAAT2 PLAAT3 PLEKHB2 PMEPA1 PNMA3 PODXL POLE2 POM121 PPIB PPIC PPIH PRAP1 PRPF40A PRR4 PSMA2 PSMA5 PSMD2 PSMD4 PSORS1C2 PTGDS QPCT RAD23A RAD23B RASSF5 RBFOX2 RBM24 RNF11 RNF128 RNF208 RNF4 RPN1 RPS27A RSRC2 RTL8A RTL8B RTL8C SCG5 SCGB2B2 SEMG1 SERPINE1 SERPINI2 SEZ6 SEZ6L SFTPA2 SGTA SLC16A3 SLC29A2 SLITRK1 SLPI SMIM11A SMIM11B SMIM19 SMIM2 SMR3B SMURF1 SNRPB SOD3 SPAG11B SPINT1 SPN SRGN SRP68 STAM2 SUOX SUSD4 TENT5B TFF3 TIMM21 TIMP2 TMEM123 TMEM31 TNFRSF18 TOMM20L TRAF4 TRIM32 TXNDC12 TXNDC5 UACA UBA52 UBAC1 UBB UBC UBE2I UBE2V1 UBE3A UBQLN1 UBQLN4 UBXN1 UBXN7 UFSP1 VENTX VIP VTN VWC2 WFDC10B WFDC12 ZFAND2A ZFAND2B ZG16 ZG16B ZNF205
Entrez ID		7077	29978
HPRD ID		01784	02224
Ensembl ID		ENSG00000035862	ENSG00000188021
Uniprot IDs		A0A140VK57 P16035	Q9UHD9
PDB IDs		1BR9 1GXD 2TMP 4ILW	1J8C 2NBV 6MUN
Enriched GO Terms of Interacting Partners?
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