TIE1 and PSG5

Data Source:
BioGRID (pull down)

		TIE1	PSG5
Description		tyrosine kinase with immunoglobulin like and EGF like domains 1	pregnancy specific beta-1-glycoprotein 5
Image			No pdb structure
GO Annotations	Cellular Component	Integral Component Of Plasma Membrane Receptor Complex	Extracellular Region
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Protein Binding
	Biological Process	Angiogenesis Vasculogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Aortic Valve Morphogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Mesoderm Development Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cell Migration Response To Retinoic Acid Positive Regulation Of Kinase Activity Plasma Membrane Fusion Positive Regulation Of Angiogenesis Tissue Remodeling Lymphatic Endothelial Cell Differentiation Branching Involved In Lymph Vessel Morphogenesis Regulation Of Extracellular Matrix Assembly	Female Pregnancy
Pathways			Cell surface interactions at the vascular wall
Drugs		Fostamatinib	Alitretinoin
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) Platelet count ( 32888494) Red blood cell count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		13 interacting genes: ANGPT1 ANGPT4 KRT40 KRTAP10-8 MDFI MTMR14 PIK3R1 PSG5 PTPN11 RBPMS TEK TRIP6 ZRANB1	3 interacting genes: NLGN3 PRPF40A TIE1
Entrez ID		7075	5673
HPRD ID		02572	08894
Ensembl ID		ENSG00000066056	ENSG00000204941
Uniprot IDs		B4DTW8 P35590	A0A024R0S1 Q15238
PDB IDs		5N06
Enriched GO Terms of Interacting Partners?
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