THBS1 and CFH

  • Data Source:
  • HPRD (in vitro)

THBS1

CFH

Description thrombospondin 1 complement factor H
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Logical memory (immediate recall) in normal cognition ( 29274321)
  • Urate levels ( 31578528)
  • Advanced age-related macular degeneration ( 26691988)
  • Age-related macular degeneration ( 20385819 20385826 22694956 23326517 23577725 23455636 23536807 20861866 21665990 15761122)
  • Age-related macular degeneration (choroidal neovascularisation) ( 22705344)
  • Age-related macular degeneration (extreme sampling) ( 23577725)
  • Age-related macular degeneration (geographic atrophy) ( 22705344)
  • Age-related macular degeneration (MTAG) ( 32277175)
  • Blood protein levels ( 29875488 28240269)
  • Chronic central serous retinopathy ( 30480742 30073298)
  • Circulating myeloperoxidase levels (serum) ( 23620142)
  • Complement C3 and C4 levels ( 23028341)
  • Complement factor H binding to malondialdehyde ( 32321835)
  • Disease progression in age-related macular degeneration ( 29346644)
  • Disease progression to choroidal neovascularization form in age-related macular degeneration ( 29346644)
  • Disease progression to geographic atrophy form in age-related macular degeneration ( 29346644)
  • Early age-related macular degeneration ( 32843070)
  • Exudative age-related macular degeneration ( 25629512)
  • Fuchs's corneal dystrophy ( 28358029)
  • Matrix metalloproteinase-8 levels ( 29212897)
  • Meningococcal disease ( 20694013)
  • Neovascular age-related macular degeneration ( 28703135)
  • Nephropathy ( 21399633)
  • Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
  • Serum C3d:C3 ratio (systemic complement activation) ( 29398083)
  • Sub-foveal choroidal thickness ( 29844195)
  • Systemic lupus erythematosus ( 28714469)
Interacting Genes 40 interacting genes: CALCR CALR CD36 CD47 CFH COL1A1 COL2A1 COL3A1 COL4A1 COL5A1 COL7A1 CORO1A CTSG DCN DHFR ELANE F2 FGA FGF2 FN1 HRG IGFBP5 ITGB3 JAG1 KNG1 LAMB3 LRP1 LRP2 LRP5 MMP2 MMP9 MTDH PDGFB PLG SCARB2 SPARC TFPI TGFB1 TNFAIP6 TNFRSF11B 16 interacting genes: ADM C3 CFHR1 CFI CRP DMP1 EP300 GRB2 ITGAM PTX3 SELL SMAD3 THBS1 VDR YTHDC1 ZBTB16
Entrez ID 7057 3075
HPRD ID 01765 00601
Ensembl ID ENSG00000137801 ENSG00000000971
Uniprot IDs P07996 A0A024R962 A0A0D9SG88 P08603
PDB IDs 1LSL 1UX6 1Z78 1ZA4 2ERF 2ES3 2OUH 2OUJ 3R6B 5FOE 1FHC 1HAQ 1HCC 1HFH 1HFI 1KOV 2BZM 2G7I 2IC4 2JGW 2JGX 2KMS 2QFG 2QFH 2RLP 2RLQ 2UWN 2V8E 2W80 2W81 2WII 2XQW 3GAU 3GAV 3GAW 3KXV 3KZJ 3OXU 3R62 3RJ3 3SW0 4AYD 4AYE 4AYI 4AYM 4B2R 4B2S 4J38 4K12 4ONT 4ZH1 5NBQ 5O32 5O35 5WTB 6ATG
Enriched GO Terms of Interacting Partners?
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