TFE3 and TFEB

Data Source:
HPRD (in vivo)

		TFE3	TFEB
Description		transcription factor binding to IGHM enhancer 3	transcription factor EB
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Cytoplasm Lysosomal Membrane Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Enzyme Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Brown Fat Cell Differentiation Negative Regulation Of Cold-induced Thermogenesis	Embryonic Placenta Development Adaptive Immune Response Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Autophagy Humoral Immune Response Lysosome Organization Cellular Response To Starvation Regulation Of Gene Expression Positive Regulation Of Autophagy Lysosome Localization Cellular Response To Amino Acid Starvation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Drugs
Diseases		Alveolar soft part sarcoma Renal cell carcinoma
GWAS			Attention deficit hyperactivity disorder ( 18839057) Blood urea nitrogen levels ( 31152163) Colorectal cancer ( 26965516 30529582) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Late-onset Alzheimer's disease ( 27770636) PR interval ( 32439900) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: E2F3 HMGB1 LAMTOR3 MITF SMAD3 SMAD4 SMARCE1 TFEB TFEC YWHAG	4 interacting genes: MITF SRPK1 TFE3 TFEC
Entrez ID		7030	7942
HPRD ID		02439	02847
Ensembl ID		ENSG00000068323	ENSG00000112561
Uniprot IDs		A0A024QZ23 B4DIA5 P19532	A0A024RCY3 B0QYS6 P19484
PDB IDs
Enriched GO Terms of Interacting Partners?
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