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TFCP2 and PSMD5
Data Source:
BioGRID
(two hybrid)
TFCP2
PSMD5
Description
transcription factor CP2
proteasome 26S subunit, non-ATPase 5
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytosol
Protein-containing Complex
Proteasome Complex
Nucleoplasm
Cytosol
Proteasome Regulatory Particle, Base Subcomplex
Proteasome Accessory Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Sequence-specific Double-stranded DNA Binding
Protein Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
MRNA Transcription By RNA Polymerase II
Positive Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Proteasome Regulatory Particle Assembly
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Systolic blood pressure (
27618452
)
Interacting Genes
74 interacting genes:
ACAA1
ADPRH
APBB1
ASAP3
BAG6
C19orf73
CA1
CAPN3
CASP8
CBX8
CDC73
COIL
DNAJC27
DNAJC5B
DPH1
E2F8
EAF1
EIF5B
EPHA10
FAM120C
FANCL
FARS2
FBXL18
GPANK1
HAPLN2
HDAC1
HDAC2
IRAK1BP1
LDB3
LSM1
MAPK1
MAPK14
MAPK8
MOB3C
MORF4L1
MRPL11
MRPL40
MVP
NABP1
NEDD9
NFE4
NHSL2
NOM1
NPEPL1
PHF1
PHF21B
PIMREG
PITPNM1
PLCB1
POLL
POLR3GL
PPIG
PPP1R1B
PPP3R2
PSMD5
RBMS1
RNF2
RXRB
SDCBP
SHTN1
SIN3A
STMN2
SUMO1
TCEA2
TDRD1
TLK1
TRAPPC12
TSPAN12
UBE2I
UBP1
YJU2
YY1
ZCCHC10
ZCCHC12
10 interacting genes:
APP
BTBD1
BTBD2
CASTOR1
LNX2
PSMC1
PSMC2
PSMD2
TFCP2
UBC
Entrez ID
7024
5711
HPRD ID
01790
05121
Ensembl ID
ENSG00000135457
ENSG00000095261
Uniprot IDs
A0A024R120
Q12800
Q16401
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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