TEC and ARHGAP6

Data Source:
BioGRID (affinity chromatography technology)

		TEC	ARHGAP6
Description		tec protein tyrosine kinase	Rho GTPase activating protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cytoskeleton Plasma Membrane	Cytoplasm Cytosol Actin Filament Actin Cytoskeleton
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Metal Ion Binding	GTPase Activator Activity Phospholipase Activator Activity SH3 Domain Binding Phospholipase Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway Tissue Regeneration Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Activation Of Phospholipase C Activity Rho Protein Signal Transduction Actin Filament Polymerization Positive Regulation Of GTPase Activity Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly
Pathways		Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling	Rho GTPase cycle
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS		Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 30423114 24390342) Systolic blood pressure ( 27841878)	Mean spheric corpuscular volume ( 32888494) Prostate cancer ( 29892016) Prostate cancer (advanced) ( 29892016)
Interacting Genes		36 interacting genes: ARHGEF12 BMX BTK DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 VAV1 WAS	1 interacting genes: LNX1
Entrez ID		7006	395
HPRD ID		02786	02124
Ensembl ID		ENSG00000135605	ENSG00000047648
Uniprot IDs		P42680	O43182 Q59HG6
PDB IDs		2LUL
Enriched GO Terms of Interacting Partners?
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