TDGF1 and NODAL

Data Source:
BioGRID (pull down)

		TDGF1	NODAL
Description		teratocarcinoma-derived growth factor 1	nodal growth differentiation factor
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Apical Plasma Membrane Extrinsic Component Of Plasma Membrane Anchored Component Of Membrane Membrane Raft	Extracellular Space
	Molecular Function	Signaling Receptor Binding Protein Binding Growth Factor Activity Nodal Binding Activin Receptor Binding	Cytokine Activity Protein Binding Growth Factor Activity Morphogen Activity Type I Activin Receptor Binding
	Biological Process	Activation Of MAPK Activity Blood Vessel Development Morphogenesis Of A Branching Structure Cell Migration Involved In Sprouting Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Determination Of Left/right Symmetry Heart Development Positive Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification, Embryo Embryo Development Ending In Birth Or Egg Hatching Anterior/posterior Pattern Specification Regulation Of Signal Transduction Positive Regulation Of Endothelial Cell Migration Peptidyl-serine Phosphorylation Cell Differentiation Positive Regulation Of Cell Migration Mammary Gland Development Somatic Stem Cell Population Maintenance Cellular Response To Hepatocyte Growth Factor Stimulus Nodal Signaling Pathway Negative Regulation Of Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Anatomical Structure Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Interferon-gamma Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Trophectodermal Cellular Morphogenesis Neural Fold Formation Liver Development Placenta Development Embryonic Placenta Development Maternal Placenta Development Vasculature Development Heart Looping Inhibition Of Neuroepithelial Cell Differentiation Brain Development Embryonic Pattern Specification Polarity Specification Of Proximal/distal Axis Regulation Of Gastrulation Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Cell Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Stem Cell Population Maintenance Positive Regulation Of Cell-cell Adhesion BMP Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Floor Plate Morphogenesis Endodermal Cell Differentiation Cell Migration Involved In Gastrulation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Axial Mesodermal Cell Fate Specification Mesendoderm Development Digestive Tract Morphogenesis Embryonic Cranial Skeleton Morphogenesis Formation Of Anatomical Boundary Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of DNA-binding Transcription Factor Activity Embryonic Process Involved In Female Pregnancy Maternal Process Involved In Parturition Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Left Lung Morphogenesis Negative Regulation Of Androgen Receptor Signaling Pathway Epiblast Cell-extraembryonic Ectoderm Cell Signaling Involved In Anterior/posterior Axis Specification Positive Regulation Of ERK1 And ERK2 Cascade Transforming Growth Factor Beta Receptor Signaling Pathway Involved In Primitive Streak Formation Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Negative Regulation Of Trophoblast Cell Migration Negative Regulation Of Chorionic Trophoblast Cell Proliferation Regulation Of Stem Cell Population Maintenance
Pathways		Signaling by NODAL Regulation of signaling by NODAL POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation	Signaling by NODAL Regulation of signaling by NODAL
Drugs
Diseases			Heterotaxy; Situs ambiguus
GWAS		Blood protein levels ( 29875488 28240269) Metabolite levels ( 23823483) Refractive error ( 32231278)
Interacting Genes		22 interacting genes: ACVR1 ACVR1B ACVR1C ACVR2A ACVR2B ANG AP2S1 BAG6 BMP4 BMP6 BMP7 BMPR1A BMPR2 COPS6 FARSA FBLN1 GDF3 GDF9 INHBB LRIF1 NODAL TGFBR2	6 interacting genes: ACVR1B ACVR2A ACVR2B KRT31 KRTAP6-3 TDGF1
Entrez ID		6997	4838
HPRD ID		01757	08370
Ensembl ID		ENSG00000241186	ENSG00000156574
Uniprot IDs		F5H1T8 P13385	Q96S42
PDB IDs			4N1D
Enriched GO Terms of Interacting Partners?
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