TCF12 and DDX6

Data Source:
BioGRID (two hybrid)

		TCF12	DDX6
Description		transcription factor 12	DEAD-box helicase 6
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Regulator Complex	Heterochromatin P-body Outer Dense Fiber Nucleus Nucleolus Cytoplasm Mitochondrion Cytosol Adherens Junction Cytoplasmic Stress Granule Membrane RISC Complex Chromatoid Body Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Concave Side Of Sperm Head Sperm Annulus
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding CAMP Response Element Binding BHLH Transcription Factor Binding SMAD Binding Protein Heterodimerization Activity E-box Binding HMG Box Domain Binding Sequence-specific Double-stranded DNA Binding	RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Protein Binding ATP Binding Protein Domain Specific Binding Cadherin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Immune Response Nervous System Development Muscle Organ Development Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Hematopoietic Stem Cell Differentiation	Negative Regulation Of Translation Viral RNA Genome Packaging Stem Cell Population Maintenance P-body Assembly Stress Granule Assembly Exonucleolytic Catabolism Of Deadenylated MRNA Negative Regulation Of Neuron Differentiation Spermatid Differentiation Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Pathways		Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription NGF-stimulated transcription	mRNA decay by 5' to 3' exoribonuclease
Drugs			D-tartaric acid
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein B levels ( 32203549) Body mass index ( 28892062) Glaucoma (primary open-angle) ( 29891935) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Male-pattern baldness ( 28196072) Mean platelet volume ( 32888494 27863252) Triglyceride levels ( 32154731) Type 2 diabetes ( 30297969)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Asthma ( 31959851 30929738 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune traits (pleiotropy) ( 30572963) Blood protein levels ( 30072576) Celiac disease ( 22057235) Celiac disease and Rheumatoid arthritis ( 26546613) Celiac disease or Rheumatoid arthritis ( 21383967) Diffuse cutaneous systemic sclerosis ( 24387989) Height ( 25429064) Hip minimal joint space width ( 27701424) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systemic lupus erythematosus ( 28714469 19838195) Systemic sclerosis ( 24387989 31672989) Vitiligo ( 22951725)
Interacting Genes		76 interacting genes: ARL16 ARMC8 ASCL3 ASCL4 BMERB1 BMF C1orf109 CDKN2C CFAP206 CKS1B CLCNKA CRCP CREBBP DDX6 DGCR6 EDRF1 EP300 EXOC8 FERD3L FIGLA FRMD6 GRB7 HAND1 HAND2 HEXIM2 HOPX ID1 ID2 ID3 LAMTOR5 LNX1 LYSMD1 MAPKBP1 MLLT6 MORN4 MSC MSGN1 MYF6 MYO15B NAGK NEK6 NEUROD1 NEUROG1 NEUROG3 NGLY1 NHLH2 OLIG3 OSGIN1 PIN1 PRKAB2 PRSS23 PSMA1 PTF1A QARS1 RBM8A RNASEL RUNX1T1 SOX10 SOX8 SPG21 SRI STAT5A STK16 TAF4 TAL2 TBC1D21 TBP TCF21 TCF23 TCF3 TRIM72 TSNAX TWIST2 VPS28 WTAP ZNF688	77 interacting genes: BEGAIN BEND7 BHLHB9 BIRC7 CALCOCO2 CCDC136 CCDC14 CEP70 CEP76 CNKSR3 CNOT1 DDX17 DES DISC1 DNAAF11 EDC3 EFHC2 ENTR1 FCHO1 GIGYF1 GOLGA2 HOOK2 IK IKZF1 INKA1 JAKMIP1 JUP KLC4 KRT34 KRT40 KRTAP10-3 KRTAP10-8 LZTS1 MAGED1 MESD MTUS2 NAB2 NONO PAK5 PDLIM7 PICK1 PNMA5 POU6F2 PRDM16 PRPH RAPGEF3 RBM11 RBM14 REL RO60 RUNDC3A SCYL1 SHMT1 SIPA1L2 SLAIN1 SORBS3 SPATA6 SRPK2 STAT1 TCF12 TCF4 TLE5 TP53BP2 TRAF2 TRIM27 TRIM37 TRIM54 U2AF2 USH1G VPS52 ZBTB10 ZBTB14 ZBTB43 ZBTB8A ZC2HC1C ZNF24 ZRANB1
Entrez ID		6938	1656
HPRD ID		02725	02638
Ensembl ID		ENSG00000140262	ENSG00000110367
Uniprot IDs		A0A024R5T1 A0A024R5Z0 F5GY10 Q99081	B2R858 P26196
PDB IDs		2KNH 4JOL	1VEC 2WAX 2WAY 4CRW 4CT4 4CT5 5ANR 6F9S 6S8S
Enriched GO Terms of Interacting Partners?
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