TAF1 and TAF15

Data Source:
HPRD (in vivo)

		TAF1	TAF15
Description		TATA-box binding protein associated factor 1	TATA-box binding protein associated factor 15
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Transcription Factor TFIID Complex Nucleolus MLL1 Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity P53 Binding Histone Acetyltransferase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding RNA Polymerase II General Transcription Initiation Factor Activity Kinase Activity TBP-class Protein Binding Nuclear Hormone Receptor Binding Sequence-specific DNA Binding Protein Heterodimerization Activity H3K27me3 Modified Histone Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Ubiquitin Conjugating Enzyme Activity Lysine-acetylated Histone Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity Transcription Regulator Inhibitor Activity Acetyl-CoA Binding	DNA Binding Transcription Coregulator Activity RNA Binding Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Transcription Initiation From RNA Polymerase I Promoter Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Cycle Negative Regulation Of Gene Expression Viral Process Histone Acetylation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Midbrain Development Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To UV Transcription Factor Catabolic Process Negative Regulation Of DNA-binding Transcription Factor Activity Protein Autophosphorylation Protein Stabilization RNA Polymerase II Preinitiation Complex Assembly Cellular Response To ATP Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Protein Autoubiquitination Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Androgen Receptor Activity	Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated MRNA Stabilization Regulation Of Signal Transduction By P53 Class Mediator
Pathways		HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases			Extraskeletal myxoid chondrosarcoma
GWAS			Blood protein levels ( 28240269) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		57 interacting genes: APC AR ASF1A ASF1B BRMS1 CCNA2 CCND1 CDC42BPA CLIP4 DNAJB5 DOCK9 DYSF EDF1 EWSR1 FOS GFI1B GTF2A1 GTF2E1 GTF2F1 H1-1 H3-4 HMGB1 HSF1 ITGB5 JUN LHX3 MAX MDM2 MSX1 MYOM2 PAX3 PRKD3 RANBP2 RB1 RBL1 RBL2 RELA SGCA SPTAN1 SUB1 SUMO2 TAF10 TAF11 TAF12 TAF15 TAF2 TAF4 TAF4B TAF5 TAF6 TAF7 TAF8 TAF9 TBP TP53 UBE2I UBTF	93 interacting genes: ARID1A CACNA1A H2AC20 H3-4 H3C1 H4C14 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I POLR2C POLR2E POLR2G SAFB SF1 SMARCA4 SMARCC1 SMARCC2 TAF1 TAF12 TAF13 TAF5 TAF7 YWHAG ZNF384
Entrez ID		6872	8148
HPRD ID		02436	09031
Ensembl ID		ENSG00000147133	ENSG00000270647
Uniprot IDs		P21675	Q92804
PDB IDs		1EQF 3AAD 3UV4 3UV5 4RGW 4YYM 4YYN 5FUR 5I1Q 5I29 5MG2 6BQD 6FIC 6MZD 6MZL 6MZM 6P38 6P39 6P3A	2MMY
Enriched GO Terms of Interacting Partners?
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