TADA2A and THOC1

Data Source:
BioGRID (two hybrid)

		TADA2A	THOC1
Description		transcriptional adaptor 2A	THO complex 1
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GO Annotations	Cellular Component	PCAF Complex Nucleus Chromosome SAGA-type Complex	Transcription Export Complex THO Complex THO Complex Part Of Transcription Export Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Nuclear Matrix Nuclear Speck
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding	DNA Binding RNA Binding Protein Binding
	Biological Process	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Histone Acetylation Histone H3 Acetylation Positive Regulation Of Transcription, DNA-templated	Regulation Of DNA Recombination RNA Processing RNA Export From Nucleus MRNA Export From Nucleus Apoptotic Process Signal Transduction RNA Splicing MRNA 3'-end Processing Replication Fork Processing Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus Negative Regulation Of Isotype Switching To IgA Isotypes Negative Regulation Of DNA Damage Checkpoint
Pathways		HATs acetylate histones	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334) Monocyte percentage of white cells ( 32888494) Ovarian cancer ( 23535730) Plateletcrit ( 32888494) White blood cell count ( 32888494)	Bipolar disorder ( 20351715) Bipolar disorder or major depressive disorder ( 20351715) Height ( 31562340) Menarche (age at onset) ( 29773799) Triglyceride levels ( 32203549)
Interacting Genes		48 interacting genes: ARNT2 C1orf109 CCDC116 CCDC134 CCHCR1 CDCA7L EIF4E2 EXOC8 FAM107A FANCG FARS2 FBF1 GPSM3 HGS HNRNPLL KAT2A KLC4 KLHL38 KPNA2 LMO1 MAGOH MAGOHB MCPH1 MFAP1 MKRN3 MTX2 MYC NOL4L-DT NR3C1 PPP1R16B PRKAB2 PRPF31 QARS1 RNF6 RTL8B SF3A3 TADA3 TCF3 TEKT4 THOC1 TTC23 TTC9C VPS25 ZCCHC12 ZFYVE26 ZNF417 ZNF564 ZNF688	26 interacting genes: AGR2 AKAP9 BHLHB9 CTAG1A CTAG1B DHX8 EXOC5 FRA10AC1 IK MAGEB4 MOAP1 MTNR1B NEDD4 PAX6 PPP1R12C RABGEF1 RB1 REL SAP30BP SF3B2 TADA2A TRIM27 TRIM54 USHBP1 WDR77 ZMYND12
Entrez ID		6871	9984
HPRD ID		03784	09498
Ensembl ID		ENSG00000276234	ENSG00000079134
Uniprot IDs		A0A024R0Y4 A0A087WWR4 B3KU13 O75478	Q96FV9
PDB IDs		1X41	1WXP
Enriched GO Terms of Interacting Partners?
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