SUV39H1 and FRMD6

Data Source:
BioGRID (two hybrid)

		SUV39H1	FRMD6
Description		suppressor of variegation 3-9 homolog 1	FERM domain containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Heterochromatin Condensed Nuclear Chromosome Nucleus Nuclear Lamina Nucleoplasm Chromatin Silencing Complex RDNA Heterochromatin	Cytoplasm Cytoskeleton Plasma Membrane
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding S-adenosylmethionine-dependent Methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Protein N-terminus Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II RDNA Heterochromatin Assembly Chromatin Organization RRNA Processing Cellular Response To DNA Damage Stimulus Cell Cycle Viral Process Cell Differentiation Histone Lysine Methylation Histone H3-K9 Dimethylation Histone H3-K9 Trimethylation Negative Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Rhythmic Process Cellular Response To Hypoxia	Actomyosin Structure Organization
Pathways		PKMTs methylate histone lysines SIRT1 negatively regulates rRNA expression
Drugs
Diseases
GWAS			Anticoagulant levels ( 22216198) Brain structure ( 20171287) Cognitive decline rate in late mild cognitive impairment ( 26252872) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hippocampal atrophy ( 19668339) Lung cancer (smoking interaction) ( 24658283) Multiple sclerosis ( 31604244) Nonsyndromic cleft lip with or without cleft palate ( 28087736) Total ventricular volume ( 21116278) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		138 interacting genes: ATE1 ATF3 ATP6V1B1 BAHD1 BCL11B C4orf17 C8orf74 CBX1 CBX3 CBX4 CBX5 CDC23 CDCA4 CDCA7L CEP70 CFAP100 CLK3 CRBN CREBBP CRELD2 DBF4B DCAF8 DDB1 DNMT1 DNMT3A DNMT3B DVL3 ELOF1 EP300 ESR1 EZH2 FGD5 FOXR2 FRMD6 FUS FYN GOLGA6L9 GPATCH2L GTF2H2C_2 GTPBP2 H3-3A H3-4 H3-5 H3C1 H3C15 HDAC1 HDAC2 HDAC3 HDAC5 HOOK2 HOXA1 HOXC4 ID1 ID2 IGFBP4 IL16 ING4 INTS2 KDM1A KLF15 KLHDC4 KLHL20 KRTAP10-7 KRTAP10-8 LDHAL6B LENG8 LHX8 LINC02875 LNX1 LOXL4 LZTS2 MALT1 MBD1 MBD4 MCRS1 MSANTD3 MTF2 MTO1 MYOD1 NR1H2 NR1H3 ODAD3 OPA3 PADI6 PHF19 PML PNKP PPP1R16A PRIM2 PRMT6 PSMC1 RASSF1 RASSF2 RB1 RBBP4 RBBP7 RBL1 RBL2 RIN3 RRP8 RSPO2 RUNX1 SBF1 SLFN12 SMAD1 SMAD5 SPATA24 SPRED1 SPSB1 SRGAP3 STX11 STX19 TEKT4 TEX35 THRA TMEM11 TNFAIP1 TNS2 TRIM41 U2AF1 WDFY3 WIZ ZBTB2 ZBTB24 ZCCHC17 ZKSCAN5 ZNF165 ZNF417 ZNF436 ZNF438 ZNF451 ZNF557 ZNF581 ZNF649 ZNF670 ZNF829 ZRANB1 ZSCAN9	27 interacting genes: - BLZF1 COX6B2 DNAJA3 EXOC5 GMCL1 HMBOX1 IKZF1 JMJD6 LZTS2 MAK16 MED4 MID2 MLH1 NKAPD1 PARD6B RASSF8 SSX2IP SUV39H1 SYT17 TCF12 TLK2 TRIM55 TRIM63 TSC22D4 WDR7 YWHAB
Entrez ID		6839	122786
HPRD ID		02221	12646
Ensembl ID		ENSG00000101945	ENSG00000139926
Uniprot IDs		O43463	Q96NE9
PDB IDs		3MTS
Enriched GO Terms of Interacting Partners?
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