TRIM21 and TNS4

Data Source:
BioGRID (two hybrid)

		TRIM21	TNS4
Description		tripartite motif containing 21	tensin 4
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol SCF Ubiquitin Ligase Complex Cytoplasmic Vesicle Ribonucleoprotein Complex	Cytosol Cytoskeleton Focal Adhesion
	Molecular Function	DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Actin Binding Protein Binding
	Biological Process	Protein Polyubiquitination Protein Monoubiquitination Cell Cycle Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Regulation Of Protein Localization Negative Regulation Of Viral Transcription Response To Interferon-gamma Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Interferon-gamma-mediated Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Protein Deubiquitination Negative Regulation Of Viral Release From Host Cell	Apoptotic Process Protein Localization
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling Antigen processing: Ubiquitination & Proteasome degradation	MET interacts with TNS proteins
Drugs
Diseases
GWAS		Lung cancer ( 28604730) Malaria ( 31844061)	Asthma ( 31959851) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)
Interacting Genes		71 interacting genes: ALOX15B APC CALR CASP8AP2 CBX4 CDC34 CUL1 CWC25 DAXX DCP2 DMAP1 DZIP3 EHHADH EXOC8 FADD FBXW11 FHOD1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GRAP HLA-DRB1 IGFN1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 LNX1 MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NIF3L1 PFKP RBCK1 RNF111 RO60 SAMHD1 SETD7 SKP2 SQSTM1 TBK1 TCP11L1 TNS4 TRIM27 TRIM3 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2E1 UBE2H UBE2I UBE2L3 UBE2N UBE2V2 UBE2W USP15 USP2 USP4 VPS9D1 XAF1 YJU2 YWHAZ ZBTB16	25 interacting genes: AR CARD9 CBL CYSRT1 EGFR ERBB3 ERBB4 GAB1 GSTCD HSF2BP KAZN KCTD4 MET NME4 NR3C1 P4HA2 PIH1D1 PIK3R1 PPP3CA RABEP1 RPAIN TRIM21 TRIM27 TXK ZRANB1
Entrez ID		6737	84951
HPRD ID		00170	12223
Ensembl ID		ENSG00000132109	ENSG00000131746
Uniprot IDs		P19474	Q6PJP3 Q8IZW8
PDB IDs		2IWG 5JPX 5OLM 6FGA 6S53
Enriched GO Terms of Interacting Partners?
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