SRI and CACNA1S

Data Source:
HPRD (in vitro)

		SRI	CACNA1S
Description		sorcin	calcium voltage-gated channel subunit alpha1 S
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Membrane Sarcoplasmic Reticulum Z Disc T-tubule Sarcoplasmic Reticulum Membrane Chromaffin Granule Membrane Axon Terminus Dendritic Spine Neck Extracellular Exosome	Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex T-tubule I Band L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Protease Binding Signaling Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Ion Channel Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding	Voltage-gated Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding
	Biological Process	Action Potential Calcium Ion Transport Intracellular Sequestering Of Iron Ion Regulation Of Striated Muscle Contraction Signal Transduction Heart Development Muscle Organ Development Regulation Of Heart Contraction Negative Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Negative Regulation Of Cardiac Muscle Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Regulation Of Relaxation Of Muscle Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Transcription Regulatory Region DNA Binding	Calcium Ion Transport Muscle Contraction Regulation Of Ion Transmembrane Transport Cardiac Conduction Calcium Ion Import Calcium Ion Transmembrane Transport Cellular Response To Caffeine
Pathways		Stimuli-sensing channels Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis Ion transport by P-type ATPases	NCAM1 interactions
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Cinnarizine Magnesium sulfate Levomenthol Ethanol Felodipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Clevidipine Nilvadipine Trimebutine Pinaverium Aranidipine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases			Hypokalemic periodic paralysis (HypoPP)
GWAS			Appendicular lean mass ( 33097823) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cardiac Troponin-T levels ( 31014085) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163 31015462 30604766) Glomerular filtration rate (creatinine) ( 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Inflammatory bowel disease ( 28067908) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Permanent tooth development ( 21931568) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Tooth agenesis ( 29364747) Ulcerative colitis ( 28067908 20228799) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		20 interacting genes: ALG2 ANXA11 ANXA7 CACNA1C CACNA1S CALCOCO2 GCA MTNR1A NRAS PDE4C PRR13 PSEN2 RYR2 SHBG SMAD2 SNCA SRPK2 STAT3 TCF12 USHBP1	8 interacting genes: CCDC106 CYSRT1 MEOX2 PDZD3 REL RIMS2 RYR1 SRI
Entrez ID		6717	779
HPRD ID		01680	00248
Ensembl ID		ENSG00000075142	ENSG00000081248
Uniprot IDs		B4DHQ6 C9J0K6 P30626	B1ALM3 Q13698
PDB IDs		1JUO 2JC2 4U8D 4UPG 4USL 5MRA	2VAY 6B27
Enriched GO Terms of Interacting Partners?
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