SQLE and ZNF641

Data Source:
BioGRID (two hybrid)

		SQLE	ZNF641
Description		squalene epoxidase	zinc finger protein 641
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytosol
	Molecular Function	Squalene Monooxygenase Activity Protein Binding FAD Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding
	Biological Process	Cholesterol Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cholesterol Metabolic Process Response To Organic Substance Sterol Biosynthetic Process Regulation Of Cell Population Proliferation Regulation Of Cholesterol Biosynthetic Process Lipid Droplet Formation	Regulation Of Transcription By RNA Polymerase II
Pathways		Cholesterol biosynthesis Activation of gene expression by SREBF (SREBP)	Generic Transcription Pathway
Drugs		Naftifine Terbinafine Butenafine Ellagic acid
Diseases
GWAS		Amyotrophic lateral sclerosis ( 24931836) Amyotrophic lateral sclerosis or frontotemporal dementia ( 24931836) Metabolite levels ( 23823483)	Estimated glomerular filtration rate ( 31152163 31015462) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Red blood cell count ( 27863252)
Interacting Genes		6 interacting genes: ALDOC CREB3 CREB3L1 REEP4 TMEM14B ZNF641	8 interacting genes: APP DTX2 KDM1A LMO1 LMO2 LMO3 SCNM1 SQLE
Entrez ID		6713	121274
HPRD ID		11802	08711
Ensembl ID		ENSG00000104549	ENSG00000167528
Uniprot IDs		Q14534 Q5HYI4	Q96N77
PDB IDs		6C6N 6C6P 6C6R
Enriched GO Terms of Interacting Partners?
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