SPI1 and ETS1

Data Source:
BioGRID (pull down)

		SPI1	ETS1
Description		Spi-1 proto-oncogene	ETS proto-oncogene 1, transcription factor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity RNA Binding Protein Binding Transcription Factor Binding NFAT Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Lymphoid Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Lymphocyte Differentiation Cell Differentiation Erythrocyte Differentiation Macrophage Differentiation Granulocyte Differentiation Somatic Stem Cell Population Maintenance Myeloid Dendritic Cell Differentiation Histone H3 Acetylation Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Regression Interleukin-6-mediated Signaling Pathway Cellular Response To Ethanol Negative Regulation Of Histone H4 Acetylation Oncogene-induced Cell Senescence Positive Regulation Of P38MAPK Cascade Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Response To Hypoxia Regulation Of Transcription By RNA Polymerase II Immune Response Female Pregnancy Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Mechanical Stimulus Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Regulation Of Extracellular Matrix Disassembly Hypothalamus Development Pituitary Gland Development Cell Differentiation PML Body Organization Response To Estradiol Response To Laminar Fluid Shear Stress Positive Regulation Of Blood Vessel Endothelial Cell Migration Estrous Cycle Positive Regulation Of Erythrocyte Differentiation Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Motility Positive Regulation Of Inflammatory Response Positive Regulation Of Cellular Component Movement Angiogenesis Involved In Wound Healing Cellular Response To Hydrogen Peroxide Response To Interleukin-1 Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Pathways		RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis	Oncogene Induced Senescence
Drugs
Diseases		Acute myeloid leukemia (AML)
GWAS		Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Apolipoprotein A1 levels ( 32203549) Blood urea nitrogen levels ( 31152163) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Experiencing mood swings ( 29500382) Familial squamous cell lung carcinoma ( 29924316) Fruit consumption ( 32066663) Global electrical heterogeneity phenotypes ( 29622589) Hematocrit ( 32888494) Hematology traits ( 30576415) Hemoglobin ( 32888494) Intraocular pressure ( 29617998 25173106) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Mean platelet volume ( 32888494) Medication use (diuretics) ( 31015401) Neuroticism ( 29255261) Refractive error ( 32231278)	Adverse response to drug ( 30420678) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) Atopic dermatitis ( 26482879) Celiac disease ( 22057235 20190752 25920553 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Depressive and manic episodes in bipolar disorder ( 26297903) Depressive episodes in bipolar disorder ( 26297903) Eczema ( 31361310) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Follicular lymphoma ( 25279986) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Granulocyte count ( 27863252) Height ( 31562340) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998 29785010 31959993 30054594) Itch intensity from mosquito bite ( 28199695) Liver fibrosis in pediatric non-alcoholic fatty acid liver disease ( 28918882) Lung function (FVC) ( 30061609) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Manganese levels ( 26025379) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494 27863252) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Obesity-related traits ( 23251661) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Psoriasis ( 25903422 23143594) Psoriasis vulgaris ( 26626624) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 22446963 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Self-reported allergy ( 23817569) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 23273568 26663301 26502338 20169177 28714469 19838193) Type 2 diabetes ( 30054458 30297969 30718926) Ulcerative colitis ( 28067908) White blood cell count ( 32888494 27863252)
Interacting Genes		45 interacting genes: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FOS FUS GATA1 GATA2 GATA3 GFI1 HDAC1 HOXA10 IRF1 IRF2 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 RUNX1 SIN3A SKI SPIB SSRP1 TBP TMX1	50 interacting genes: APLP2 APP ARID4B ARL6IP4 ATF2 BRCA1 CAMK2A CAMK2B COP1 CREBBP CYBC1 DAXX DNMT3L EIF5B EP300 ETS2 FOS GATA3 HTATIP2 JUN MAF MAPK1 MAPK3 MAPK7 MED23 MEIS1 NCL NCOR1 NFKB1 NR3C1 PARP1 PAX5 POU1F1 RBBP6 RPL13A RUNX1T1 RUNX2 SMAD3 SP1 SP100 SPI1 SRA1 SRC SRSF11 STAT5B STAT6 TBP TDP2 UBE2I XRCC6
Entrez ID		6688	2113
HPRD ID		01305	01260
Ensembl ID		ENSG00000066336	ENSG00000134954
Uniprot IDs		P17947	A8K725 B4DW78 P14921
PDB IDs			1GVJ 2NNY 2STT 2STW 3MFK 3RI4 3WTS 3WTT 3WTU 3WTV 3WTW 3WTX 3WTY 3WTZ 3WU0 3WU1 4L0Y 4L0Z 4L18 4LG0 5ZMC
Enriched GO Terms of Interacting Partners?
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